{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(4)"],"submitter":["Kalayci A"],"funding":["Roche","Roche Diagnostics","Hutter Family Professorship"],"pubmed_abstract":["Aims
Concentrations of insulin-like growth factor binding protein-7 (IGFBP7) have been linked to abnormal cardiac structure and function in patients with chronic heart failure (HF), but cardiovascular correlates of the biomarker in patients with more acute presentations are lacking. We aimed to determine the relationship between IGFBP7 concentrations and cardiac structure and to evaluate the impact of IGFBP7 on the diagnosis of acute HF among patients with acute dyspnoea.Methods and results
In this pre-specified subgroup analysis of the International Collaborative of N-terminal pro-B-type Natriuretic Peptide Re-evaluation of Acute Diagnostic Cut-Offs in the Emergency Department (ICON-RELOADED) study, we included 271 patients with and without acute HF. All patients presented"],"journal":["ESC heart failure"],"pagination":["1664-1675"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7373911"],"repository":["biostudies-literature"],"pubmed_title":["Echocardiographic assessment of insulin-like growth factor binding protein-7 and early identification of acute heart failure."],"pmcid":["PMC7373911"],"pubmed_authors":["Cannon CM","Chen-Tournoux A","Lurie MD","Kalayci A","Cheng RK","Kastner P","Januzzi JL","Nagurney JT","Pang PS","Gaggin HK","Levy PD","Singer AJ","Peacock WF","Blomkalns AL","Nowak RM","Christenson RH","Shapiro NI","Walters EL","Masson S","Hollander JE","Gibson CM"],"additional_accession":[]},"is_claimable":false,"name":"Echocardiographic assessment of insulin-like growth factor binding protein-7 and early identification of acute heart failure.","description":"Aims
Concentrations of insulin-like growth factor binding protein-7 (IGFBP7) have been linked to abnormal cardiac structure and function in patients with chronic heart failure (HF), but cardiovascular correlates of the biomarker in patients with more acute presentations are lacking. We aimed to determine the relationship between IGFBP7 concentrations and cardiac structure and to evaluate the impact of IGFBP7 on the diagnosis of acute HF among patients with acute dyspnoea.Methods and results
In this pre-specified subgroup analysis of the International Collaborative of N-terminal pro-B-type Natriuretic Peptide Re-evaluation of Acute Diagnostic Cut-Offs in the Emergency Department (ICON-RELOADED) study, we included 271 patients with and without acute HF. All patients presented","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2025-04-19T11:35:55.693Z","creation":"2025-04-19T11:35:55.693Z"},"accession":"S-EPMC7373911","cross_references":{"pubmed":["32406612"],"doi":["10.1002/ehf2.12722"]}}