{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(4)"],"submitter":["Cork DP"],"funding":["Edwards Lifesciences"],"pubmed_abstract":["<h4>Aims</h4>Heart failure (HF) carries a poor prognosis, and the impact of concomitant mitral regurgitation (MR) is not well understood. This analysis aimed to estimate the incremental effect of MR in patients newly diagnosed with HF.<h4>Methods and results</h4>Data from the IBM® MarketScan® Research Databases were analysed. Included patients had at least one inpatient or two outpatient HF claims. A 6 month post-period after HF index was used to capture MR diagnosis and severity. HF patients were separated into three cohorts: without MR (no MR), not clinically significant MR (nsMR), and significant MR (sMR). Time-to-event analyses were modelled to estimate the clinical burden of disease. The primary outcome was a composite endpoint of death or cardiovascular (CV)-related admission. Second"],"journal":["ESC heart failure"],"pagination":["1502-1509"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7373926"],"repository":["biostudies-literature"],"pubmed_title":["Impact of mitral regurgitation on cardiovascular hospitalization and death in newly diagnosed heart failure patients."],"pmcid":["PMC7373926"],"pubmed_authors":["Baker ER","Barker CM","Cork DP","Van Houten J","Mollenkopf S","McCullough PA","Mehta HS","Ryan MP","Gunnarsson C","Verta P"],"additional_accession":[]},"is_claimable":false,"name":"Impact of mitral regurgitation on cardiovascular hospitalization and death in newly diagnosed heart failure patients.","description":"<h4>Aims</h4>Heart failure (HF) carries a poor prognosis, and the impact of concomitant mitral regurgitation (MR) is not well understood. This analysis aimed to estimate the incremental effect of MR in patients newly diagnosed with HF.<h4>Methods and results</h4>Data from the IBM® MarketScan® Research Databases were analysed. Included patients had at least one inpatient or two outpatient HF claims. A 6 month post-period after HF index was used to capture MR diagnosis and severity. HF patients were separated into three cohorts: without MR (no MR), not clinically significant MR (nsMR), and significant MR (sMR). Time-to-event analyses were modelled to estimate the clinical burden of disease. The primary outcome was a composite endpoint of death or cardiovascular (CV)-related admission. Second","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2025-04-19T11:36:21.954Z","creation":"2025-04-19T11:36:21.954Z"},"accession":"S-EPMC7373926","cross_references":{"pubmed":["32469120"],"doi":["10.1002/ehf2.12653"]}}