biostudies-literatureUnknown7(4)Cork DPEdwards Lifesciences<h4>Aims</h4>Heart failure (HF) carries a poor prognosis, and the impact of concomitant mitral regurgitation (MR) is not well understood. This analysis aimed to estimate the incremental effect of MR in patients newly diagnosed with HF.<h4>Methods and results</h4>Data from the IBM® MarketScan® Research Databases were analysed. Included patients had at least one inpatient or two outpatient HF claims. A 6 month post-period after HF index was used to capture MR diagnosis and severity. HF patients were separated into three cohorts: without MR (no MR), not clinically significant MR (nsMR), and significant MR (sMR). Time-to-event analyses were modelled to estimate the clinical burden of disease. The primary outcome was a composite endpoint of death or cardiovascular (CV)-related admission. SecondESC heart failure1502-1509https://www.ebi.ac.uk/biostudies/studies/S-EPMC7373926biostudies-literatureImpact of mitral regurgitation on cardiovascular hospitalization and death in newly diagnosed heart failure patients.PMC7373926Baker ERBarker CMCork DPVan Houten JMollenkopf SMcCullough PAMehta HSRyan MPGunnarsson CVerta PfalseImpact of mitral regurgitation on cardiovascular hospitalization and death in newly diagnosed heart failure patients.<h4>Aims</h4>Heart failure (HF) carries a poor prognosis, and the impact of concomitant mitral regurgitation (MR) is not well understood. This analysis aimed to estimate the incremental effect of MR in patients newly diagnosed with HF.<h4>Methods and results</h4>Data from the IBM® MarketScan® Research Databases were analysed. Included patients had at least one inpatient or two outpatient HF claims. A 6 month post-period after HF index was used to capture MR diagnosis and severity. HF patients were separated into three cohorts: without MR (no MR), not clinically significant MR (nsMR), and significant MR (sMR). Time-to-event analyses were modelled to estimate the clinical burden of disease. The primary outcome was a composite endpoint of death or cardiovascular (CV)-related admission. Second2020-01-01T00:00:00Z2020 Aug2025-04-19T11:36:21.954Z2025-04-19T11:36:21.954ZS-EPMC73739263246912010.1002/ehf2.12653