{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xia Y"],"funding":["National Natural Science Foundation of China"],"pagination":["313"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7374834"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["<h4>Background</h4>Small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSC) derived from human induced pluripotent stem cells (iPSC, iMSC-sEV) are considered to have great potential in treating ischemic diseases. Angiogenesis play an important role in post-stroke recovery. However, no studies have yet been conducted to systemically examine the effect and the underlying mechanism of iMSC-sEV on angiogenesis under brain ischemia conditions.<h4>Methods</h4>Ischemic stroke model was performed in rats induced by middle cerebral artery occlusion (MCAO), and the pro-angiogenic capacity of iMSC-sEV was measured. The in vitro effects of iMSC-sEV on the migration and tube formation of endothelial cells were investigated, respectively. Autophagy and autophagy-related signaling path"],"journal":["Stem cell research & therapy"],"pubmed_title":["Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke."],"pmcid":["PMC7374834"],"funding_grant_id":["81671209","81870972","81871833"],"pubmed_authors":["Xia Y","Ling X","Zhang J","Zhao B","Hu G","Deng Z","Li Q","Wang Y","Zhu Q"],"additional_accession":[]},"is_claimable":false,"name":"Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke.","description":"<h4>Background</h4>Small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSC) derived from human induced pluripotent stem cells (iPSC, iMSC-sEV) are considered to have great potential in treating ischemic diseases. Angiogenesis play an important role in post-stroke recovery. However, no studies have yet been conducted to systemically examine the effect and the underlying mechanism of iMSC-sEV on angiogenesis under brain ischemia conditions.<h4>Methods</h4>Ischemic stroke model was performed in rats induced by middle cerebral artery occlusion (MCAO), and the pro-angiogenic capacity of iMSC-sEV was measured. The in vitro effects of iMSC-sEV on the migration and tube formation of endothelial cells were investigated, respectively. Autophagy and autophagy-related signaling path","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-04T22:32:15.142Z","creation":"2025-04-04T22:32:15.142Z"},"accession":"S-EPMC7374834","cross_references":{"pubmed":["32698909"],"doi":["10.1186/s13287-020-01834-0"]}}