biostudies-literatureBallav CNational Institute for Health Research (NIHR)NNF Center for Basic Metabolic ResearchUniversity of Oxforde00130https://www.ebi.ac.uk/biostudies/studies/S-EPMC7375047biostudies-literatureUnknown3(3)<h4>Aims</h4>The GLP1 agonist lixisenatide is glucagonostatic and reduces post-prandial blood glucose (PPBG) in type 2 diabetes. This study investigates its impact in type 1 diabetes (T1D).<h4>Methods</h4>In a blinded, crossover trial, 25 patients with T1D were randomised to 4 weeks adjunctive treatment with lixisenatide (L) or placebo (P), with a 4-week washout period. The primary outcome was percentage of 3 hours PPBG in target (4-10 mmol/L) assessed by CGM before and after treatment. Participants also underwent post-treatment standardised mixed meal test (MMT, n = 25) and hyperinsulinaemic hypoglycaemic clamp (n = 15).<h4>Results</h4>PPBG CGM readings in target were similar between L vs P (Mean % ± SE, breakfast 45.4 ± 6.0 vs 44.3 ± 6.0, <i>P</i> = .48, lunch 45.5 ± 5.8 vs 50.6 ± 5.3, <Endocrinology, diabetes & metabolismLixisenatide in type 1 diabetes: A randomised control trial of the effect of lixisenatide on post-meal glucose excursions and glucagon in type 1 diabetes patients.PMC7375047NF-SI-0515-10096Holst GroupDhere AAgbaje OFBallav CFranklin RHolst JJHolman RRWhite SHartmann BOwen KRKennedy IfalseLixisenatide in type 1 diabetes: A randomised control trial of the effect of lixisenatide on post-meal glucose excursions and glucagon in type 1 diabetes patients.<h4>Aims</h4>The GLP1 agonist lixisenatide is glucagonostatic and reduces post-prandial blood glucose (PPBG) in type 2 diabetes. This study investigates its impact in type 1 diabetes (T1D).<h4>Methods</h4>In a blinded, crossover trial, 25 patients with T1D were randomised to 4 weeks adjunctive treatment with lixisenatide (L) or placebo (P), with a 4-week washout period. The primary outcome was percentage of 3 hours PPBG in target (4-10 mmol/L) assessed by CGM before and after treatment. Participants also underwent post-treatment standardised mixed meal test (MMT, n = 25) and hyperinsulinaemic hypoglycaemic clamp (n = 15).<h4>Results</h4>PPBG CGM readings in target were similar between L vs P (Mean % ± SE, breakfast 45.4 ± 6.0 vs 44.3 ± 6.0, <i>P</i> = .48, lunch 45.5 ± 5.8 vs 50.6 ± 5.3, <2020-01-01T00:00:00Z2020 Jul2025-04-19T11:39:18.772Z2025-04-19T11:39:18.772ZS-EPMC73750473270455510.1002/edm2.130