biostudies-literatureUnknown3(3)Arnold SV<h4>Background</h4>A number of non-low-density lipoprotein cholesterol lipid abnormalities are associated with type 2 diabetes and insulin resistance, which may lead practitioners to use medications targeting these abnormal lipid fractions despite a lack of evidence or guideline recommendations.<h4>Methods and results</h4>Among 382 921 US patients with type 2 diabetes (69% with cardiovascular disease, 76% on a statin), 95 995 (26%) were on some nonstatin lipid-lowering medication-19 265 (5%) on niacin, 32 919 (9%) on a fibrate and 69 513 (18%) on fish oil. Use of all three medications was stable over time and higher in patients with cardiovascular disease and with higher triglyceride levels, although even among patients with triglyceride levels <2.3 mmol/L, 6% were on a fibrate and 17% werEndocrinology, diabetes & metabolisme00126https://www.ebi.ac.uk/biostudies/studies/S-EPMC7375067biostudies-literatureUse of non-LDL-C lipid-lowering medications in patients with type 2 diabetes.PMC7375067Wong NDArnold SVKosiborod MGoyal AGosch KHejjaji VLeiter LAfalseUse of non-LDL-C lipid-lowering medications in patients with type 2 diabetes.<h4>Background</h4>A number of non-low-density lipoprotein cholesterol lipid abnormalities are associated with type 2 diabetes and insulin resistance, which may lead practitioners to use medications targeting these abnormal lipid fractions despite a lack of evidence or guideline recommendations.<h4>Methods and results</h4>Among 382 921 US patients with type 2 diabetes (69% with cardiovascular disease, 76% on a statin), 95 995 (26%) were on some nonstatin lipid-lowering medication-19 265 (5%) on niacin, 32 919 (9%) on a fibrate and 69 513 (18%) on fish oil. Use of all three medications was stable over time and higher in patients with cardiovascular disease and with higher triglyceride levels, although even among patients with triglyceride levels <2.3 mmol/L, 6% were on a fibrate and 17% wer2020-01-01T00:00:00Z2020 Jul2026-07-15T23:38:25.551Z2025-04-19T11:39:56.453ZS-EPMC73750673270455210.1002/edm2.126