biostudies-literatureKim SHNIEHS NIH HHSKorea Health Industry Development Institutee037780https://www.ebi.ac.uk/biostudies/studies/S-EPMC7375628biostudies-literatureUnknown10(7)<h4>Introduction</h4>Coronary CT angiography (CCTA) is widely used for non-invasive coronary artery evaluation, but it is limited in identifying the nature of functional characteristics that cause ischaemia. Recent computational fluid dynamic (CFD) techniques applied to CCTA images permit non-invasive computation of fractional flow reserve (FFR), a measure of lesion-specific ischaemia. However, this technology has limitations, such as long computational time and the need for expensive equipment, which hinder widespread use.<h4>Methods and analysis</h4>This study is a prospective, multicentre, comparative and confirmatory trial designed to evaluate the diagnostic performance of HeartMedi V.1.0, a novel CT-derived FFR measurement for the detection of haemodynamically significant coronary artBMJ openValidation of the diagnostic performance of 'HeartMedi V.1.0', a novel CT-derived fractional flow reserve measurement, for patients with coronary artery disease: a study protocol.PMC737562827306C2006HI17C2006Kang SHKwon KHYoun TJChung WYByun YSBae JWKim SHYoon CHDoh JHPark SDNam CWChae IHfalseValidation of the diagnostic performance of 'HeartMedi V.1.0', a novel CT-derived fractional flow reserve measurement, for patients with coronary artery disease: a study protocol.<h4>Introduction</h4>Coronary CT angiography (CCTA) is widely used for non-invasive coronary artery evaluation, but it is limited in identifying the nature of functional characteristics that cause ischaemia. Recent computational fluid dynamic (CFD) techniques applied to CCTA images permit non-invasive computation of fractional flow reserve (FFR), a measure of lesion-specific ischaemia. However, this technology has limitations, such as long computational time and the need for expensive equipment, which hinder widespread use.<h4>Methods and analysis</h4>This study is a prospective, multicentre, comparative and confirmatory trial designed to evaluate the diagnostic performance of HeartMedi V.1.0, a novel CT-derived FFR measurement for the detection of haemodynamically significant coronary art2020-01-01T00:00:00Z2020 Jul2026-06-03T03:26:30.277Z2024-11-21T00:39:03.596ZS-EPMC73756283269074810.1136/bmjopen-2020-037780