{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yoon CI"],"funding":["NRF","Ministry of Science, ICT, &amp; Future Planning","Ministry of Health &amp; Welfare, Republic of Korea","National R&amp;D Program for Cancer Control"],"pagination":["141-148"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7375640"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["50"],"pubmed_abstract":["<h4>Introduction</h4>Tumor-infiltrating lymphocytes (TILs) might be associated with host-cell mediated immunity, which could be partly reflected by peripheral blood cell counts. In addition, lymphocyte-predominant breast cancer (LPBC), which was defined as tumors having high TIL levels, showed a favorable prognosis among triple-negative breast cancer or HER2-positive breast cancer. We aimed to investigate whether peripheral blood cell counts are associated with LPBC.<h4>Methods</h4>We evaluated the percentage of stromal TILs in breast cancer patients who underwent primary surgery, using the standardized methodology proposed by the international TIL Working Group. Lymphocyte-predominant breast cancer (LPBC) was defined as tumors having high TIL levels (≥50%). Peripheral blood cell counts including absolute neutrophil counts (ANC), absolute lymphocyte counts (ALC) and neutrophil-to-lymphocyte ratio (NLR) was obtained from pretreatment laboratory data.<h4>Result</h4>Of the 810 patients, 132 (16.3%) had LPBC, and 678 (83.7%) had non-LBPC. In a comparison of 3 markers of peripheral blood counts, LPBC had a significantly lower mean ANC than non-LPBC (3,304 vs. 3,564; P = 0.023), but the other means were not different. In multivariable analysis, each 1K increment in ANC corresponded to an odds ratio of 0.790 (95% CI, 0.642 to 0.971) for LPBC. In the ER-negative and high-Ki67 subgroups identified by interaction tests, significant inverse correlations between continuous ANC and TILs were noted.<h4>Conclusion</h4>Low peripheral ANC could be linked with LPBC, supporting the hypothesis that systemic immune cell counts might be associated with the tumor-immune microenvironment."],"journal":["Breast (Edinburgh, Scotland)"],"pubmed_title":["Associations between absolute neutrophil count and lymphocyte-predominant breast cancer."],"pmcid":["PMC7375640"],"funding_grant_id":["1520120","NRF-2019R1C1C1002830"],"pubmed_authors":["Jeong J","Yoon CI","Lee HS","Bae SJ","Lee DY","Ahn SG","Park S","Cha YJ","Cha C"],"additional_accession":[]},"is_claimable":false,"name":"Associations between absolute neutrophil count and lymphocyte-predominant breast cancer.","description":"<h4>Introduction</h4>Tumor-infiltrating lymphocytes (TILs) might be associated with host-cell mediated immunity, which could be partly reflected by peripheral blood cell counts. In addition, lymphocyte-predominant breast cancer (LPBC), which was defined as tumors having high TIL levels, showed a favorable prognosis among triple-negative breast cancer or HER2-positive breast cancer. We aimed to investigate whether peripheral blood cell counts are associated with LPBC.<h4>Methods</h4>We evaluated the percentage of stromal TILs in breast cancer patients who underwent primary surgery, using the standardized methodology proposed by the international TIL Working Group. Lymphocyte-predominant breast cancer (LPBC) was defined as tumors having high TIL levels (≥50%). Peripheral blood cell counts including absolute neutrophil counts (ANC), absolute lymphocyte counts (ALC) and neutrophil-to-lymphocyte ratio (NLR) was obtained from pretreatment laboratory data.<h4>Result</h4>Of the 810 patients, 132 (16.3%) had LPBC, and 678 (83.7%) had non-LBPC. In a comparison of 3 markers of peripheral blood counts, LPBC had a significantly lower mean ANC than non-LPBC (3,304 vs. 3,564; P = 0.023), but the other means were not different. In multivariable analysis, each 1K increment in ANC corresponded to an odds ratio of 0.790 (95% CI, 0.642 to 0.971) for LPBC. In the ER-negative and high-Ki67 subgroups identified by interaction tests, significant inverse correlations between continuous ANC and TILs were noted.<h4>Conclusion</h4>Low peripheral ANC could be linked with LPBC, supporting the hypothesis that systemic immune cell counts might be associated with the tumor-immune microenvironment.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2025-04-19T11:38:27.717Z","creation":"2025-04-19T11:38:27.717Z"},"accession":"S-EPMC7375640","cross_references":{"pubmed":["31607527"],"doi":["10.1016/j.breast.2019.09.013"]}}