biostudies-literatureUnknown109(8)Ter Maaten JM<h4>Background</h4>Loop diuretics are frequently prescribed to patients with heart failure and reduced ejection fraction (HFrEF) for the treatment of congestion; however, they might hamper uptitration of inhibitors of the renin-angiotensin system.<h4>Methods</h4>Loop diuretic dose at baseline was recorded in 2338 patients with HFrEF enrolled in BIOSTAT-CHF, an international study of HF patients on loop diuretic therapy who were eligible for uptitration of angiotensin-converting enzyme inhibitors (ACEi)/mineralocorticoid receptor antagonists (MRA). The association between loop diuretic dose and uptitration of ACEi/MRA to percentage of target dose was adjusted for a previously published model for likelihood of uptitration and a propensity score.<h4>Results</h4>Baseline median loop diuretic dClinical research in cardiology : official journal of the German Cardiac Society1048-1059https://www.ebi.ac.uk/biostudies/studies/S-EPMC7375987biostudies-literatureHigher doses of loop diuretics limit uptitration of angiotensin-converting enzyme inhibitors in patients with heart failure and reduced ejection fraction.PMC7375987Ter Maaten JMMartens PZannad FCleland JGMetra MHillege HLDamman KLang CCSamani NJVoors AADickstein KAnker SDFilippatos GMullens WNg LLPonikowski Pvan Veldhuisen DJfalseHigher doses of loop diuretics limit uptitration of angiotensin-converting enzyme inhibitors in patients with heart failure and reduced ejection fraction.<h4>Background</h4>Loop diuretics are frequently prescribed to patients with heart failure and reduced ejection fraction (HFrEF) for the treatment of congestion; however, they might hamper uptitration of inhibitors of the renin-angiotensin system.<h4>Methods</h4>Loop diuretic dose at baseline was recorded in 2338 patients with HFrEF enrolled in BIOSTAT-CHF, an international study of HF patients on loop diuretic therapy who were eligible for uptitration of angiotensin-converting enzyme inhibitors (ACEi)/mineralocorticoid receptor antagonists (MRA). The association between loop diuretic dose and uptitration of ACEi/MRA to percentage of target dose was adjusted for a previously published model for likelihood of uptitration and a propensity score.<h4>Results</h4>Baseline median loop diuretic d2020-01-01T00:00:00Z2020 Aug2025-04-05T12:42:34.136Z2025-04-05T12:42:34.136ZS-EPMC73759873200263110.1007/s00392-020-01598-w