biostudies-literatureEchodu RDELTAS Africa Initiative grantWellcome Trust348https://www.ebi.ac.uk/biostudies/studies/S-EPMC7376877biostudies-literatureUnknown13(1)<h4>Objective</h4>The aim of the study was to determine the level of insecticide resistance and diversity in Anopheles mosquitoes in northern Uganda. Standard WHO insecticide susceptibility test assays were used to test for susceptibility to 0.5% malathion, 0.1% bendiocarb, 0.05% deltamethrin and 0.75% permethrin on 3-5 day old generation one progeny. We also screened for species diversity and knockdown resistance using PCR assay.<h4>Results</h4>Anopheles gambiae s.s. is the predominant malaria vector in northern Uganda followed by An. arabiensis. An. gambiae s.s. was susceptible to malathion and bendiocarb with the observed mortality rate of 100% and 98-100% observed respectively while very high resistance was observed with deltamethrin and permethrin. Minimal KDR-eastern variant homozygoBMC research notesHigh insecticide resistances levels in Anopheles gambiaes s.l. in northern Uganda and its relevance for future malaria control.PMC7376877107742/Z/15/ZDEL-15-011Opiyo EALutwama JJOnanyang DEchodu RIwiru TOyet WSIga JAnena JMireji PfalseHigh insecticide resistances levels in Anopheles gambiaes s.l. in northern Uganda and its relevance for future malaria control.<h4>Objective</h4>The aim of the study was to determine the level of insecticide resistance and diversity in Anopheles mosquitoes in northern Uganda. Standard WHO insecticide susceptibility test assays were used to test for susceptibility to 0.5% malathion, 0.1% bendiocarb, 0.05% deltamethrin and 0.75% permethrin on 3-5 day old generation one progeny. We also screened for species diversity and knockdown resistance using PCR assay.<h4>Results</h4>Anopheles gambiae s.s. is the predominant malaria vector in northern Uganda followed by An. arabiensis. An. gambiae s.s. was susceptible to malathion and bendiocarb with the observed mortality rate of 100% and 98-100% observed respectively while very high resistance was observed with deltamethrin and permethrin. Minimal KDR-eastern variant homozygo2020-01-01T00:00:00Z2020 Jul2025-05-29T14:37:55.132Z2024-10-19T04:23:20.206ZS-EPMC73768773269884410.1186/s13104-020-05193-0