{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Eichmann M"],"funding":["NIDDK NIH HHS","National Institute for Health Research (NIHR)","National Institutes of Health"],"pagination":["3129-3138"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7378361"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["204(12)"],"pubmed_abstract":["We previously reported that costimulation blockade by abatacept limits the decline of β-cell function and the frequency of circulating CD4<sup>+</sup> central memory T cells (T<sub>CM</sub>) (CD45RO<sup>+</sup>CD62L<sup>+</sup>) in new-onset type 1 diabetes. In human subjects receiving placebo, we found a significant association between an increase in CD4<sup>+</sup> T<sub>CM</sub> cells and the decline of β-cell function. To extend and refine these findings, we examined changes in human CD4<sup>+</sup> and CD8<sup>+</sup> naive and memory T cell subsets at greater resolution using polychromatic flow and mass cytometry. In the placebo group, we successfully reproduced the original finding of a significant association between T<sub>CM</sub> and β-cell function and extended this to other T c"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Costimulation Blockade Disrupts CD4<sup>+</sup> T Cell Memory Pathways and Uncouples Their Link to Decline in β-Cell Function in Type 1 Diabetes."],"pmcid":["PMC7378361"],"funding_grant_id":["U01 DK085461","U01 DK061010","U01 DK061042","U01 DK061034","U01 DK085476","U01 DK085465","DP3DK101109","U01 DK085466","U01 DK085499","U01 DK061058","U01 DK103180","U01 DK085509","UC4 DK106993","U01 DK107013","U01 DK107014","U01 DK106994","U01 DK106984","U01 DK103266","U01 DK103153","DP3 DK101109","U01 DK103282"],"pubmed_authors":["Ellis RJ","Heck S","Peakman M","Beam CA","Baptista R","Eichmann M"],"additional_accession":[]},"is_claimable":false,"name":"Costimulation Blockade Disrupts CD4<sup>+</sup> T Cell Memory Pathways and Uncouples Their Link to Decline in β-Cell Function in Type 1 Diabetes.","description":"We previously reported that costimulation blockade by abatacept limits the decline of β-cell function and the frequency of circulating CD4<sup>+</sup> central memory T cells (T<sub>CM</sub>) (CD45RO<sup>+</sup>CD62L<sup>+</sup>) in new-onset type 1 diabetes. In human subjects receiving placebo, we found a significant association between an increase in CD4<sup>+</sup> T<sub>CM</sub> cells and the decline of β-cell function. To extend and refine these findings, we examined changes in human CD4<sup>+</sup> and CD8<sup>+</sup> naive and memory T cell subsets at greater resolution using polychromatic flow and mass cytometry. In the placebo group, we successfully reproduced the original finding of a significant association between T<sub>CM</sub> and β-cell function and extended this to other T c","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2026-05-02T16:44:10.879Z","creation":"2022-02-10T14:49:13.384Z"},"accession":"S-EPMC7378361","cross_references":{"pubmed":["32404353"],"doi":["10.4049/jimmunol.1901439"]}}