biostudies-literatureEichmann MNIDDK NIH HHSNational Institute for Health Research (NIHR)National Institutes of Health3129-3138https://www.ebi.ac.uk/biostudies/studies/S-EPMC7378361biostudies-literatureUnknown204(12)We previously reported that costimulation blockade by abatacept limits the decline of β-cell function and the frequency of circulating CD4⁺ central memory T cells (T_CM) (CD45RO⁺CD62L⁺) in new-onset type 1 diabetes. In human subjects receiving placebo, we found a significant association between an increase in CD4⁺ T_CM cells and the decline of β-cell function. To extend and refine these findings, we examined changes in human CD4⁺ and CD8⁺ naive and memory T cell subsets at greater resolution using polychromatic flow and mass cytometry. In the placebo group, we successfully reproduced the original finding of a significant association between T_CM and β-cell function and extended this to other T cJournal of immunology (Baltimore, Md. : 1950)Costimulation Blockade Disrupts CD4⁺ T Cell Memory Pathways and Uncouples Their Link to Decline in β-Cell Function in Type 1 Diabetes.PMC7378361U01 DK085461U01 DK061010U01 DK061042U01 DK061034U01 DK085476U01 DK085465DP3DK101109U01 DK085466U01 DK085499U01 DK061058U01 DK103180U01 DK085509UC4 DK106993U01 DK107013U01 DK107014U01 DK106994U01 DK106984U01 DK103266U01 DK103153DP3 DK101109U01 DK103282Ellis RJHeck SPeakman MBeam CABaptista REichmann MfalseCostimulation Blockade Disrupts CD4⁺ T Cell Memory Pathways and Uncouples Their Link to Decline in β-Cell Function in Type 1 Diabetes.We previously reported that costimulation blockade by abatacept limits the decline of β-cell function and the frequency of circulating CD4⁺ central memory T cells (T_CM) (CD45RO⁺CD62L⁺) in new-onset type 1 diabetes. In human subjects receiving placebo, we found a significant association between an increase in CD4⁺ T_CM cells and the decline of β-cell function. To extend and refine these findings, we examined changes in human CD4⁺ and CD8⁺ naive and memory T cell subsets at greater resolution using polychromatic flow and mass cytometry. In the placebo group, we successfully reproduced the original finding of a significant association between T_CM and β-cell function and extended this to other T c2020-01-01T00:00:00Z2020 Jun2026-05-02T16:44:10.879Z2022-02-10T14:49:13.384ZS-EPMC73783613240435310.4049/jimmunol.1901439