{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xiao H"],"funding":["Ministry of Science and Technology of the People's Republic of China","National Natural Science Foundation of China","Natural Science Foundation of Guangdong Province"],"pagination":["1208-1222"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7379385"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(7)"],"pubmed_abstract":["Tumor-associated macrophages (TAMs) usually display the tumor-promoting M2 phenotype rather than the tumoricidal M1 phenotype. Thus, M2-to-M1 repolarization of TAMs has emerged as a promising strategy for tumor immunotherapy nowadays. However, immune side effects remain a great challenge, because phenotypic conversion of macrophages into the proinflammatory M1 phenotype may also be induced in normal tissue. Here, aiming at repolarizing TAMs without altering the M1/M2 polarization balance in healthy organs, we develop a micellar nanodrug with M2-targeting peptides (M2peptide) hidden in the pH-sheddable PEG corona so that an active targeting of M2-like macrophages is triggered only in the acidic tumor microenvironment (TME). The smart nanodrug effectively functions M2-to-M1 repolarization vi"],"journal":["ACS central science"],"pubmed_title":["M2-Like Tumor-Associated Macrophage-Targeted Codelivery of STAT6 Inhibitor and IKKβ siRNA Induces M2-to-M1 Repolarization for Cancer Immunotherapy with Low Immune Side Effects."],"pmcid":["PMC7379385"],"funding_grant_id":["31971296","51933011","2014A030312018","2015CB755500"],"pubmed_authors":["Li X","Cheng D","Guo Y","Xiao H","Li B","Shuai X","Wang Y","Han S"],"additional_accession":[]},"is_claimable":false,"name":"M2-Like Tumor-Associated Macrophage-Targeted Codelivery of STAT6 Inhibitor and IKKβ siRNA Induces M2-to-M1 Repolarization for Cancer Immunotherapy with Low Immune Side Effects.","description":"Tumor-associated macrophages (TAMs) usually display the tumor-promoting M2 phenotype rather than the tumoricidal M1 phenotype. Thus, M2-to-M1 repolarization of TAMs has emerged as a promising strategy for tumor immunotherapy nowadays. However, immune side effects remain a great challenge, because phenotypic conversion of macrophages into the proinflammatory M1 phenotype may also be induced in normal tissue. Here, aiming at repolarizing TAMs without altering the M1/M2 polarization balance in healthy organs, we develop a micellar nanodrug with M2-targeting peptides (M2peptide) hidden in the pH-sheddable PEG corona so that an active targeting of M2-like macrophages is triggered only in the acidic tumor microenvironment (TME). The smart nanodrug effectively functions M2-to-M1 repolarization vi","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-06-01T02:54:41.032Z","creation":"2025-06-01T02:54:41.032Z"},"accession":"S-EPMC7379385","cross_references":{"pubmed":["32724855"],"doi":["10.1021/acscentsci.9b01235"]}}