{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen N"],"funding":["National Key Technology R&amp;D Program","Ministry of Science and Technology","Science and Technology Commission of Shanghai Municipality","Peking University","Ministry of Health","National Institute of Diabetes and Digestive and Kidney Diseases","Shanghai Jiao Tong University School of Medicine","Management of Chronic Kidney Disease","Siemens","National Natural Science Foundation of China","Multi-Center Clinical Research"],"pagination":["172-180"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7380432"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(2)"],"pubmed_abstract":["<h4>Rationale & objectives</h4>Estimated glomerular filtration rate (eGFR) using creatinine and cystatin C (eGFR<sub>cr-cys</sub>) may be less accurate compared to measured GFR (mGFR) in China than in North America, Europe, and Australia due to variation across regions in their non-GFR determinants. The non-GFR determinants of β<sub>2</sub>-microglobulin (B2M) and β-trace protein (BTP) differ from those of creatinine and cystatin C. Thus, the average eGFR using all 4 markers (eGFR<sub>avg</sub>) could be more accurate than eGFR<sub>cr-cys</sub> in China.<h4>Study design</h4>Diagnostic test study.<h4>Setting & participants</h4>1,066 participants in Shanghai and Beijing with creatinine and cystatin C and 666 participants with all 4 filtration markers.<h4>Tests compared</h4>Index tests were p"],"journal":["Kidney medicine"],"pubmed_title":["GFR Estimation Using a Panel of Filtration Markers in Shanghai and Beijing."],"pmcid":["PMC7380432"],"funding_grant_id":["81301296","BMU2018MX020","R01DK097020","13430720800","91846101","81771938","DLY201510","2016YFC1305400","201502010","PKU2017LCX05"],"pubmed_authors":["Chen N","Karger AB","Pan Y","Minji W","Miao S","Sui Z","Zhang L","Zuo L","Ren H","Zhang W","Levey AS","Xie D","Simon A","Okparavero A","Xie J","Wang W","Eckfeldt JH","Shi H","Chaudhari J","Inker LA"],"additional_accession":[]},"is_claimable":false,"name":"GFR Estimation Using a Panel of Filtration Markers in Shanghai and Beijing.","description":"<h4>Rationale & objectives</h4>Estimated glomerular filtration rate (eGFR) using creatinine and cystatin C (eGFR<sub>cr-cys</sub>) may be less accurate compared to measured GFR (mGFR) in China than in North America, Europe, and Australia due to variation across regions in their non-GFR determinants. The non-GFR determinants of β<sub>2</sub>-microglobulin (B2M) and β-trace protein (BTP) differ from those of creatinine and cystatin C. Thus, the average eGFR using all 4 markers (eGFR<sub>avg</sub>) could be more accurate than eGFR<sub>cr-cys</sub> in China.<h4>Study design</h4>Diagnostic test study.<h4>Setting & participants</h4>1,066 participants in Shanghai and Beijing with creatinine and cystatin C and 666 participants with all 4 filtration markers.<h4>Tests compared</h4>Index tests were p","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar-Apr","modification":"2025-04-21T17:03:34.919Z","creation":"2025-04-21T17:03:34.919Z"},"accession":"S-EPMC7380432","cross_references":{"pubmed":["32734236"],"doi":["10.1016/j.xkme.2019.11.004"]}}