biostudies-literatureChen NNational Key Technology R&amp;D ProgramMinistry of Science and TechnologyScience and Technology Commission of Shanghai MunicipalityPeking UniversityMinistry of HealthNational Institute of Diabetes and Digestive and Kidney DiseasesShanghai Jiao Tong University School of MedicineManagement of Chronic Kidney DiseaseSiemensNational Natural Science Foundation of ChinaMulti-Center Clinical Research172-180https://www.ebi.ac.uk/biostudies/studies/S-EPMC7380432biostudies-literatureUnknown2(2)<h4>Rationale & objectives</h4>Estimated glomerular filtration rate (eGFR) using creatinine and cystatin C (eGFR_cr-cys) may be less accurate compared to measured GFR (mGFR) in China than in North America, Europe, and Australia due to variation across regions in their non-GFR determinants. The non-GFR determinants of β₂-microglobulin (B2M) and β-trace protein (BTP) differ from those of creatinine and cystatin C. Thus, the average eGFR using all 4 markers (eGFR_avg) could be more accurate than eGFR_cr-cys in China.<h4>Study design</h4>Diagnostic test study.<h4>Setting & participants</h4>1,066 participants in Shanghai and Beijing with creatinine and cystatin C and 666 participants with all 4 filtration markers.<h4>Tests compared</h4>Index tests were pKidney medicineGFR Estimation Using a Panel of Filtration Markers in Shanghai and Beijing.PMC738043281301296BMU2018MX020R01DK097020134307208009184610181771938DLY2015102016YFC1305400201502010PKU2017LCX05Chen NKarger ABPan YMinji WMiao SSui ZZhang LZuo LRen HZhang WLevey ASXie DSimon AOkparavero AXie JWang WEckfeldt JHShi HChaudhari JInker LAfalseGFR Estimation Using a Panel of Filtration Markers in Shanghai and Beijing.<h4>Rationale & objectives</h4>Estimated glomerular filtration rate (eGFR) using creatinine and cystatin C (eGFR_cr-cys) may be less accurate compared to measured GFR (mGFR) in China than in North America, Europe, and Australia due to variation across regions in their non-GFR determinants. The non-GFR determinants of β₂-microglobulin (B2M) and β-trace protein (BTP) differ from those of creatinine and cystatin C. Thus, the average eGFR using all 4 markers (eGFR_avg) could be more accurate than eGFR_cr-cys in China.<h4>Study design</h4>Diagnostic test study.<h4>Setting & participants</h4>1,066 participants in Shanghai and Beijing with creatinine and cystatin C and 666 participants with all 4 filtration markers.<h4>Tests compared</h4>Index tests were p2020-01-01T00:00:00Z2020 Mar-Apr2025-04-21T17:03:34.919Z2025-04-21T17:03:34.919ZS-EPMC73804323273423610.1016/j.xkme.2019.11.004