biostudies-literatureUnknown10(7)Fuller G<h4>Objectives</h4>To determine the feasibility of a large-scale definitive multicentre trial of prehospital continuous positive airway pressure (CPAP) in acute respiratory failure.<h4>Design</h4>A single-centre, open-label, individual patient randomised, controlled, external pilot trial.<h4>Setting</h4>A single UK Ambulance Service, between August 2017 and July 2018.<h4>Participants</h4>Adults with respiratory distress and peripheral oxygen saturations below British Thoracic Society target levels despite controlled oxygen treatment.<h4>Interventions</h4>Patients were randomised to prehospital CPAP (O-Two system) versus standard oxygen therapy in a 1:1 ratio using simple randomisation.<h4>Primary and secondary outcome measures</h4>Feasibility outcomes comprised recruitment rate, adherence BMJ opene035915https://www.ebi.ac.uk/biostudies/studies/S-EPMC7380855biostudies-literatureIs a definitive trial of prehospital continuous positive airway pressure versus standard oxygen therapy for acute respiratory failure indicated? The ACUTE pilot randomised controlled trial.PMC7380855Marsh MHerbert EKeating SBradburn MMiller JHarris TScott AWard MGoodacre SGunson IThokala PPerkins GFuller GCooper CRosser AfalseIs a definitive trial of prehospital continuous positive airway pressure versus standard oxygen therapy for acute respiratory failure indicated? The ACUTE pilot randomised controlled trial.<h4>Objectives</h4>To determine the feasibility of a large-scale definitive multicentre trial of prehospital continuous positive airway pressure (CPAP) in acute respiratory failure.<h4>Design</h4>A single-centre, open-label, individual patient randomised, controlled, external pilot trial.<h4>Setting</h4>A single UK Ambulance Service, between August 2017 and July 2018.<h4>Participants</h4>Adults with respiratory distress and peripheral oxygen saturations below British Thoracic Society target levels despite controlled oxygen treatment.<h4>Interventions</h4>Patients were randomised to prehospital CPAP (O-Two system) versus standard oxygen therapy in a 1:1 ratio using simple randomisation.<h4>Primary and secondary outcome measures</h4>Feasibility outcomes comprised recruitment rate, adherence 2020-01-01T00:00:00Z2020 Jul2025-04-05T15:18:29.87Z2025-04-05T15:18:29.87ZS-EPMC73808553270964310.1136/bmjopen-2019-035915