{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chaturvedi S"],"funding":["NIAID NIH HHS","NIH HHS"],"pagination":["17240-17248"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7382263"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["117(29)"],"pubmed_abstract":["Probabilistic bet hedging, a strategy to maximize fitness in unpredictable environments by matching phenotypic variability to environmental variability, is theorized to account for the evolution of various fate-specification decisions, including viral latency. However, the molecular mechanisms underlying bet hedging remain unclear. Here, we report that large variability in protein abundance within individual herpesvirus virion particles enables probabilistic bet hedging between viral replication and latency. Superresolution imaging of individual virions of the human herpesvirus cytomegalovirus (CMV) showed that virion-to-virion levels of pp71 tegument protein-the major viral transactivator protein-exhibit extreme variability. This super-Poissonian tegument variability promoted alternate re"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["A molecular mechanism for probabilistic bet hedging and its role in viral latency."],"pmcid":["PMC7382263"],"funding_grant_id":["R01 AI079059","P30 AI027763","DP2 OD006677","R37 AI079059"],"pubmed_authors":["Calvert M","Weinberger LS","Goodrum F","Moorman NJ","Vardi N","Chaturvedi S","Wolf M","Klein J","Du K","Huang B","Bolovan-Fritts C","Mlera L"],"additional_accession":[]},"is_claimable":false,"name":"A molecular mechanism for probabilistic bet hedging and its role in viral latency.","description":"Probabilistic bet hedging, a strategy to maximize fitness in unpredictable environments by matching phenotypic variability to environmental variability, is theorized to account for the evolution of various fate-specification decisions, including viral latency. However, the molecular mechanisms underlying bet hedging remain unclear. Here, we report that large variability in protein abundance within individual herpesvirus virion particles enables probabilistic bet hedging between viral replication and latency. Superresolution imaging of individual virions of the human herpesvirus cytomegalovirus (CMV) showed that virion-to-virion levels of pp71 tegument protein-the major viral transactivator protein-exhibit extreme variability. This super-Poissonian tegument variability promoted alternate re","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-05T15:19:32.303Z","creation":"2025-04-05T15:19:32.303Z"},"accession":"S-EPMC7382263","cross_references":{"pubmed":["32632017"],"doi":["10.1073/pnas.1914430117"]}}