{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(1)"],"submitter":["Guan W"],"funding":["Natural Sciences and Engineering Research Council of Canada","Heart and Stroke Foundation of Canada"],"pubmed_abstract":["Invertebrate LCa<sub>V</sub>3 shares the quintessential features of vertebrate Ca<sub>V</sub>3 T-type channels, with a low threshold of channel activation, rapid activation and inactivation kinetics and slow deactivation kinetics compared to other known Ca<sup>2+</sup> channels, the Ca<sub>V</sub>1 and Ca<sub>V</sub>2 channels. Unlike the vertebrates though, Ca<sub>V</sub>3 T-type channels in non-cnidarian invertebrates possess an alternative exon 12 spanning the D2L5 extracellular loop, which alters the invertebrate LCa<sub>V</sub>3 channel into a higher Na<sup>+</sup> and lower Ca<sup>2+</sup> current passing channel, more resembling a classical Na<sub>V</sub>1 Na<sup>+</sup> channel. Cnidarian Ca<sub>V</sub>3 T-type channels can possess genes with alternative cysteine-rich, D4L6 extrace"],"journal":["Scientific reports"],"pagination":["12404"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7382465"],"repository":["biostudies-literature"],"pubmed_title":["Unique cysteine-enriched, D2L5 and D4L6 extracellular loops in Ca<sub>V</sub>3 T-type channels alter the passage and block of monovalent and divalent ions."],"pmcid":["PMC7382465"],"pubmed_authors":["Fux J","Stephens RF","Guan W","Mehta A","Mourad O","Spafford JD"],"additional_accession":[]},"is_claimable":false,"name":"Unique cysteine-enriched, D2L5 and D4L6 extracellular loops in Ca<sub>V</sub>3 T-type channels alter the passage and block of monovalent and divalent ions.","description":"Invertebrate LCa<sub>V</sub>3 shares the quintessential features of vertebrate Ca<sub>V</sub>3 T-type channels, with a low threshold of channel activation, rapid activation and inactivation kinetics and slow deactivation kinetics compared to other known Ca<sup>2+</sup> channels, the Ca<sub>V</sub>1 and Ca<sub>V</sub>2 channels. Unlike the vertebrates though, Ca<sub>V</sub>3 T-type channels in non-cnidarian invertebrates possess an alternative exon 12 spanning the D2L5 extracellular loop, which alters the invertebrate LCa<sub>V</sub>3 channel into a higher Na<sup>+</sup> and lower Ca<sup>2+</sup> current passing channel, more resembling a classical Na<sub>V</sub>1 Na<sup>+</sup> channel. Cnidarian Ca<sub>V</sub>3 T-type channels can possess genes with alternative cysteine-rich, D4L6 extrace","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2026-05-03T00:07:08.214Z","creation":"2020-11-08T09:38:31Z"},"accession":"S-EPMC7382465","cross_references":{"pubmed":["32710088"],"doi":["10.1038/s41598-020-69197-3"]}}