{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(2)"],"submitter":["Saxena AK"],"pubmed_abstract":["<h4>Background</h4>The present study has been designed with the aim of evaluating A-kinase anchoring proteins 3 (<i>AKAP3</i>) and Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (<i>PLOD3</i>) gene mutations and prediction of 3D protein structure for ligand binding activity in the cases of non-obstructive azoospermic male.<h4>Materials and methods</h4>Clinically diagnosed cases of non-obstructive azoospermia (n=111) with age matched controls (n=42) were included in the present case-control study for genetics analysis and confirmation of diagnosis. The sample size was calculated using Epi info software version 6 with 90 power and 95% confidence interval. Genomic DNA was isolated from blood (2.0 ml) and a selected case was used for whole exome sequencing (WES) using Illumina Hiseq for id"],"journal":["International journal of fertility & sterility"],"pagination":["102-109"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7382683"],"repository":["biostudies-literature"],"pubmed_title":["Prediction of 3D Protein Structure Based on The Mutation of <i>AKAP3</i> and <i>PLOD3</i> Genes in The Case of Non-Obstructive Azoospermia."],"pmcid":["PMC7382683"],"pubmed_authors":["Agarwal M","Aniket Kumar A","Saxena AK","Tiwari M"],"additional_accession":[]},"is_claimable":false,"name":"Prediction of 3D Protein Structure Based on The Mutation of <i>AKAP3</i> and <i>PLOD3</i> Genes in The Case of Non-Obstructive Azoospermia.","description":"<h4>Background</h4>The present study has been designed with the aim of evaluating A-kinase anchoring proteins 3 (<i>AKAP3</i>) and Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (<i>PLOD3</i>) gene mutations and prediction of 3D protein structure for ligand binding activity in the cases of non-obstructive azoospermic male.<h4>Materials and methods</h4>Clinically diagnosed cases of non-obstructive azoospermia (n=111) with age matched controls (n=42) were included in the present case-control study for genetics analysis and confirmation of diagnosis. The sample size was calculated using Epi info software version 6 with 90 power and 95% confidence interval. Genomic DNA was isolated from blood (2.0 ml) and a selected case was used for whole exome sequencing (WES) using Illumina Hiseq for id","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-06-01T03:23:13.38Z","creation":"2020-11-09T08:46:52Z"},"accession":"S-EPMC7382683","cross_references":{"pubmed":["32681621"],"doi":["10.22074/ijfs.2020.6028"]}}