{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tsai CM"],"funding":["NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["333-343"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7383293"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(4)"],"pubmed_abstract":["Pathogenic microorganisms are sensed by the inflammasome, resulting in the release of the pro-immune and proinflammatory cytokine interleukin-1β (IL-1β). In humans, the paired <underline>s</underline>ialic acid-binding Ig-like lectin receptors Siglec-5 (inhibitory) and Siglec-14 (activating) have been shown to have reciprocal roles in regulating macrophage immune responses, but their interaction with IL-1β signaling and the inflammasome has not been characterized. Here we show that in response to known inflammasome activators (ATP, nigericin) or the sialic acid-expressing human bacterial pathogen group B Streptococcus (GBS), the presence of Siglec-14 enhances, whereas Siglec-5 reduces, inflammasome activation and macrophage IL-1β release. Human THP-1 macrophages stably transfected with Sig"],"journal":["Journal of innate immunity"],"pubmed_title":["Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages."],"pmcid":["PMC7383293"],"funding_grant_id":["K12 GM068524","P01 HL107150"],"pubmed_authors":["Varki A","Fong JJ","Liu JZ","Hughes G","Tsai CM","Ali SR","Nizet V","Riestra AM"],"additional_accession":[]},"is_claimable":false,"name":"Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages.","description":"Pathogenic microorganisms are sensed by the inflammasome, resulting in the release of the pro-immune and proinflammatory cytokine interleukin-1β (IL-1β). In humans, the paired <underline>s</underline>ialic acid-binding Ig-like lectin receptors Siglec-5 (inhibitory) and Siglec-14 (activating) have been shown to have reciprocal roles in regulating macrophage immune responses, but their interaction with IL-1β signaling and the inflammasome has not been characterized. Here we show that in response to known inflammasome activators (ATP, nigericin) or the sialic acid-expressing human bacterial pathogen group B Streptococcus (GBS), the presence of Siglec-14 enhances, whereas Siglec-5 reduces, inflammasome activation and macrophage IL-1β release. Human THP-1 macrophages stably transfected with Sig","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-04T07:40:33.17Z","creation":"2025-04-04T07:40:33.17Z"},"accession":"S-EPMC7383293","cross_references":{"pubmed":["31805552"],"doi":["10.1159/000504323"]}}