{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Watanabe K"],"funding":["MEXT | Japan Society for the Promotion of Science","Japan Agency for Medical Research and Development"],"pagination":["10092-10111"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7383374"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["295(30)"],"pubmed_abstract":["Aortic dissection is a life-threatening aortopathy involving separation of the aortic wall, whose underlying mechanisms are still incompletely understood. Epidemiological evidence suggests that unsaturated fatty acids improve cardiovascular health. Here, using quantitative RT-PCR, histological analyses, magnetic cell sorting and flow cytometry assays, and MS-based lipidomics, we show that the activity of a lipid-metabolizing enzyme, secreted phospholipase A<sub>2</sub> group V (sPLA<sub>2</sub>-V), protects against aortic dissection by endogenously mobilizing vasoprotective lipids. Global and endothelial cell-specific sPLA<sub>2</sub>-V-deficient mice frequently developed aortic dissection shortly after infusion of angiotensin II (AT-II). We observed that in the AT-II-treated aorta, endoth"],"journal":["The Journal of biological chemistry"],"pubmed_title":["Group V secreted phospholipase A<sub>2</sub> plays a protective role against aortic dissection."],"pmcid":["PMC7383374"],"funding_grant_id":["KAKENHI","CREST","FORCE"],"pubmed_authors":["Kugiyama K","Murakami M","Watanabe K","Taketomi Y","Miki Y"],"additional_accession":[]},"is_claimable":false,"name":"Group V secreted phospholipase A<sub>2</sub> plays a protective role against aortic dissection.","description":"Aortic dissection is a life-threatening aortopathy involving separation of the aortic wall, whose underlying mechanisms are still incompletely understood. Epidemiological evidence suggests that unsaturated fatty acids improve cardiovascular health. Here, using quantitative RT-PCR, histological analyses, magnetic cell sorting and flow cytometry assays, and MS-based lipidomics, we show that the activity of a lipid-metabolizing enzyme, secreted phospholipase A<sub>2</sub> group V (sPLA<sub>2</sub>-V), protects against aortic dissection by endogenously mobilizing vasoprotective lipids. Global and endothelial cell-specific sPLA<sub>2</sub>-V-deficient mice frequently developed aortic dissection shortly after infusion of angiotensin II (AT-II). We observed that in the AT-II-treated aorta, endoth","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-04T07:40:34.662Z","creation":"2025-04-04T07:40:34.662Z"},"accession":"S-EPMC7383374","cross_references":{"pubmed":["32482892"],"doi":["10.1074/jbc.ra120.013753","10.1074/jbc.RA120.013753"]}}