biostudies-literatureJorgensen IFNovo Nordisk Foundation Center for Protein ResearchInnovationsfondenNovo Nordisk Fonden908-917https://www.ebi.ac.uk/biostudies/studies/S-EPMC7383608biostudies-literatureUnknown16(6)<h4>Introduction</h4>Similar symptoms, comorbidities and suboptimal diagnostic tests make the distinction between different types of dementia difficult, although this is essential for improved work-up and treatment optimization.<h4>Methods</h4>We calculated temporal disease trajectories of earlier multi-morbidities in Alzheimer's disease (AD) dementia and vascular dementia (VaD) patients using the Danish National Patient Registry covering all hospital encounters in Denmark (1994 to 2016). Subsequently, we reduced the comorbidity space dimensionality using a non-linear technique, uniform manifold approximation and projection.<h4>Results</h4>We found 49,112 and 24,101 patients that were diagnosed with AD or VaD, respectively. Temporal disease trajectories showed very similar disease patternsAlzheimer's & dementia : the journal of the Alzheimer's AssociationAge-stratified longitudinal study of Alzheimer's and vascular dementia patients.PMC7383608NNF17OC0027594NNF14CC0001PI Søren Brunak5184‐00102BBrunak SLademann MJorgensen IFAguayo-Orozco AfalseAge-stratified longitudinal study of Alzheimer's and vascular dementia patients.<h4>Introduction</h4>Similar symptoms, comorbidities and suboptimal diagnostic tests make the distinction between different types of dementia difficult, although this is essential for improved work-up and treatment optimization.<h4>Methods</h4>We calculated temporal disease trajectories of earlier multi-morbidities in Alzheimer's disease (AD) dementia and vascular dementia (VaD) patients using the Danish National Patient Registry covering all hospital encounters in Denmark (1994 to 2016). Subsequently, we reduced the comorbidity space dimensionality using a non-linear technique, uniform manifold approximation and projection.<h4>Results</h4>We found 49,112 and 24,101 patients that were diagnosed with AD or VaD, respectively. Temporal disease trajectories showed very similar disease patterns2020-01-01T00:00:00Z2020 Jun2025-04-29T10:49:39.578Z2025-04-06T19:42:30.752ZS-EPMC73836083234267110.1002/alz.12091