biostudies-literatureMachulda MMNIA NIH HHSNINDS NIH HHSNational Institutes of HealthNIH HHS1013-1022https://www.ebi.ac.uk/biostudies/studies/S-EPMC7383989biostudies-literatureUnknown16(7)<h4>Introduction</h4>We examined differences in cortical thickness in empirically derived mild cognitive impairment (MCI) subtypes in the Mayo Clinic Study of Aging.<h4>Methods</h4>We compared cortical thickness of four incident MCI subtypes (n = 192) to 1257 cognitive unimpaired individuals.<h4>Results</h4>The subtle cognitive impairment cluster had atrophy in the entorhinal and parahippocampal cortex. The amnestic, dysnomic, and dysexecutive clusters also demonstrated entorhinal cortex atrophy as well as thinning in temporal, parietal, and frontal isocortex in somewhat different patterns.<h4>Discussion</h4>We found patterns of atrophy in each of the incident MCI clusters that corresponded to their patterns of cognitive impairment. The identification of MCI subtypes based on cognitive andAlzheimer's & dementia : the journal of the Alzheimer's AssociationCortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging.PMC7383989R37 AG011378U01 AG06786R01 AG041851P50 AG016574R01 AG49810U01 AG006786R01 AG011378R01 AG034676R01 AG056366R01 AG049810P30 AG062429R01 NS097495Albertson SMMielke MMBondi MWLundt ESJack CRKnopman DSKremers WKPetersen RCSchwarz CGMachulda MMJones DTSpychalla AJVemuri PfalseCortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging.<h4>Introduction</h4>We examined differences in cortical thickness in empirically derived mild cognitive impairment (MCI) subtypes in the Mayo Clinic Study of Aging.<h4>Methods</h4>We compared cortical thickness of four incident MCI subtypes (n = 192) to 1257 cognitive unimpaired individuals.<h4>Results</h4>The subtle cognitive impairment cluster had atrophy in the entorhinal and parahippocampal cortex. The amnestic, dysnomic, and dysexecutive clusters also demonstrated entorhinal cortex atrophy as well as thinning in temporal, parietal, and frontal isocortex in somewhat different patterns.<h4>Discussion</h4>We found patterns of atrophy in each of the incident MCI clusters that corresponded to their patterns of cognitive impairment. The identification of MCI subtypes based on cognitive and2020-01-01T00:00:00Z2020 Jul2025-04-19T23:01:03.532Z2025-04-19T23:01:03.532ZS-EPMC73839893241836710.1002/alz.12108