{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(37)"],"submitter":["Cardinale L"],"funding":["Alexander von Humboldt-Stiftung"],"pubmed_abstract":["Functionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C1 -molecule, carbon dioxide, makes alternative carboxylation reactions with CO2 -surrogates especially important. We report a photoredox-catalyzed protocol for alkene carbamoylations. Readily accessible 4-carboxamido-Hantzsch esters serve as convenient starting materials that generate carbamoyl radicals upon visible light-mediated single-electron transfer. Addition to various alkenes proceeded with high levels of regio- and chemoselectivity."],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pagination":["8239-8243"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7384035"],"repository":["biostudies-literature"],"pubmed_title":["Photoredox-Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4-Dihydropyridine Approach."],"pmcid":["PMC7384035"],"pubmed_authors":["Konev MO","Cardinale L","Jacobi von Wangelin A"],"additional_accession":[]},"is_claimable":false,"name":"Photoredox-Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4-Dihydropyridine Approach.","description":"Functionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C1 -molecule, carbon dioxide, makes alternative carboxylation reactions with CO2 -surrogates especially important. We report a photoredox-catalyzed protocol for alkene carbamoylations. Readily accessible 4-carboxamido-Hantzsch esters serve as convenient starting materials that generate carbamoyl radicals upon visible light-mediated single-electron transfer. Addition to various alkenes proceeded with high levels of regio- and chemoselectivity.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-19T23:01:38.974Z","creation":"2025-04-19T23:01:38.974Z"},"accession":"S-EPMC7384035","cross_references":{"pubmed":["32428293"],"doi":["10.1002/chem.202002410"]}}