biostudies-literatureUnknown26(37)Cardinale LAlexander von Humboldt-StiftungFunctionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C1 -molecule, carbon dioxide, makes alternative carboxylation reactions with CO2 -surrogates especially important. We report a photoredox-catalyzed protocol for alkene carbamoylations. Readily accessible 4-carboxamido-Hantzsch esters serve as convenient starting materials that generate carbamoyl radicals upon visible light-mediated single-electron transfer. Addition to various alkenes proceeded with high levels of regio- and chemoselectivity.Chemistry (Weinheim an der Bergstrasse, Germany)8239-8243https://www.ebi.ac.uk/biostudies/studies/S-EPMC7384035biostudies-literaturePhotoredox-Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4-Dihydropyridine Approach.PMC7384035Konev MOCardinale LJacobi von Wangelin AfalsePhotoredox-Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4-Dihydropyridine Approach.Functionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C1 -molecule, carbon dioxide, makes alternative carboxylation reactions with CO2 -surrogates especially important. We report a photoredox-catalyzed protocol for alkene carbamoylations. Readily accessible 4-carboxamido-Hantzsch esters serve as convenient starting materials that generate carbamoyl radicals upon visible light-mediated single-electron transfer. Addition to various alkenes proceeded with high levels of regio- and chemoselectivity.2020-01-01T00:00:00Z2020 Jul2025-04-19T23:01:38.974Z2025-04-19T23:01:38.974ZS-EPMC73840353242829310.1002/chem.202002410