biostudies-literatureHarteveld AAStichting voor de Technische WetenschappenNICHD NIH HHSFoundation for the National Institutes of HealthWellcome TrustEngineering and Physical Sciences Research Council1828-1843https://www.ebi.ac.uk/biostudies/studies/S-EPMC7384055biostudies-literatureUnknown84(4)<h4>Purpose</h4>Placental function is key for successful human pregnancies. Perfusion may be a sensitive marker for the in vivo assessment of placental function. Arterial spin labeling (ASL) MRI enables noninvasive measurement of tissue perfusion and it was recently suggested that ASL with velocity-selective (VS) labeling could be advantageous in the placenta. We systematically evaluated essential VS-ASL sequence parameters to determine optimal settings for efficient placental perfusion measurements.<h4>Methods</h4>Eleven pregnant women were scanned at 3T using VS-ASL with 2D multislice echo planar imaging (EPI)-readout. One reference VS-ASL scan was acquired in all subjects; within subgroups the following parameters were systematically varied: cutoff velocity, velocity encoding direction,Magnetic resonance in medicineSystematic evaluation of velocity-selective arterial spin labeling settings for placental perfusion measurement.PMC7384055Human Placenta Project, 1U01HD087202‐01201374/Z/16/ZU01 HD087202N018702 and M02053314951Sir Henry Wellcome Fellowship, 201374/Z/16/ZWT 203148/Z/16/ZRutherford Mvan Osch MJPHutter JFranklin SLHajnal JVJackson LHHarteveld AADe Vita EBos CfalseSystematic evaluation of velocity-selective arterial spin labeling settings for placental perfusion measurement.<h4>Purpose</h4>Placental function is key for successful human pregnancies. Perfusion may be a sensitive marker for the in vivo assessment of placental function. Arterial spin labeling (ASL) MRI enables noninvasive measurement of tissue perfusion and it was recently suggested that ASL with velocity-selective (VS) labeling could be advantageous in the placenta. We systematically evaluated essential VS-ASL sequence parameters to determine optimal settings for efficient placental perfusion measurements.<h4>Methods</h4>Eleven pregnant women were scanned at 3T using VS-ASL with 2D multislice echo planar imaging (EPI)-readout. One reference VS-ASL scan was acquired in all subjects; within subgroups the following parameters were systematically varied: cutoff velocity, velocity encoding direction,2020-01-01T00:00:00Z2020 Oct2025-04-19T23:01:57.758Z2025-04-19T23:01:57.758ZS-EPMC73840553214165510.1002/mrm.28240