{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nardo AD"],"funding":["Austrian Science Fund FWF"],"pagination":["1620-1633"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7384114"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(7)"],"pubmed_abstract":["<h4>Background & aims</h4>Osteopontin, a multifunctional protein and inflammatory cytokine, is overexpressed in adipose tissue and liver in obesity and contributes to the induction of adipose tissue inflammation and non-alcoholic fatty liver (NAFL). Studies performed in both mice and humans also point to a potential role for OPN in malignant transformation and tumour growth. To fully understand the role of OPN on the development of NAFL-derived hepatocellular carcinoma (HCC), we applied a non-alcoholic steatohepatitis (NASH)-HCC mouse model on osteopontin-deficient (Spp1<sup>-/-</sup> ) mice analysing time points of NASH, fibrosis and HCC compared to wild-type mice.<h4>Methods</h4>Two-day-old wild-type and Spp1<sup>-/-</sup> mice received a low-dose streptozotocin injection in order to ind"],"journal":["Liver international : official journal of the International Association for the Study of the Liver"],"pubmed_title":["Impact of osteopontin on the development of non-alcoholic liver disease and related hepatocellular carcinoma."],"pmcid":["PMC7384114"],"funding_grant_id":["W1205‐B09"],"pubmed_authors":["Oberhuber G","Helbich TH","Markgraf DF","Grun NG","Dumanic M","Roden M","Zeyda M","Nardo AD","Rivelles E","Trauner M","Stulnig TM","Claudel T"],"additional_accession":[]},"is_claimable":false,"name":"Impact of osteopontin on the development of non-alcoholic liver disease and related hepatocellular carcinoma.","description":"<h4>Background & aims</h4>Osteopontin, a multifunctional protein and inflammatory cytokine, is overexpressed in adipose tissue and liver in obesity and contributes to the induction of adipose tissue inflammation and non-alcoholic fatty liver (NAFL). Studies performed in both mice and humans also point to a potential role for OPN in malignant transformation and tumour growth. To fully understand the role of OPN on the development of NAFL-derived hepatocellular carcinoma (HCC), we applied a non-alcoholic steatohepatitis (NASH)-HCC mouse model on osteopontin-deficient (Spp1<sup>-/-</sup> ) mice analysing time points of NASH, fibrosis and HCC compared to wild-type mice.<h4>Methods</h4>Two-day-old wild-type and Spp1<sup>-/-</sup> mice received a low-dose streptozotocin injection in order to ind","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-19T23:02:54.917Z","creation":"2025-04-19T23:02:54.917Z"},"accession":"S-EPMC7384114","cross_references":{"pubmed":["32281248"],"doi":["10.1111/liv.14464"]}}