biostudies-literatureUnknown144(6)Malmgren L<h4>Background/aims</h4>Prospective data on age-related changes in kidney function are required, especially since the current Kidney Disease Improving Global Outcomes (KDIGO) definition has been suggested to classify a large number of elderly people with CKD.<h4>Objective</h4>This study, a complement to our previous Cr-based study in the same cohort, is aimed at evaluating cystatin C (cysC)-based changes in kidney function during aging in older women and analyzing the association between CKD and mortality through 10 years of follow-up.<h4>Methods</h4>cysC was available in 981 women from the Osteoporosis Prospective Risk Assessment (OPRA) cohort, all aged 75 years on entry. Reinvestigations were made after 5 (n = 685) and 10 years (n = 365). Kidney function was estimated (estimated glomerulNephron290-298https://www.ebi.ac.uk/biostudies/studies/S-EPMC7384338biostudies-literatureLongitudinal Changes in Kidney Function Estimated from Cystatin C and Its Association with Mortality in Elderly Women.PMC7384338Malmgren LMcGuigan FEChristensson AAkesson KEfalseLongitudinal Changes in Kidney Function Estimated from Cystatin C and Its Association with Mortality in Elderly Women.<h4>Background/aims</h4>Prospective data on age-related changes in kidney function are required, especially since the current Kidney Disease Improving Global Outcomes (KDIGO) definition has been suggested to classify a large number of elderly people with CKD.<h4>Objective</h4>This study, a complement to our previous Cr-based study in the same cohort, is aimed at evaluating cystatin C (cysC)-based changes in kidney function during aging in older women and analyzing the association between CKD and mortality through 10 years of follow-up.<h4>Methods</h4>cysC was available in 981 women from the Osteoporosis Prospective Risk Assessment (OPRA) cohort, all aged 75 years on entry. Reinvestigations were made after 5 (n = 685) and 10 years (n = 365). Kidney function was estimated (estimated glomerul2020-01-01T00:00:00Z20202025-04-19T23:04:48.648Z2025-04-19T23:04:48.648ZS-EPMC73843383239256110.1159/000507256