biostudies-literatureSato YMinistry of Health, Labour and WelfareJapan Agency for Medical Research and Developmente0236602https://www.ebi.ac.uk/biostudies/studies/S-EPMC7384644biostudies-literatureUnknown15(7)A significant relationship exists between elevated uric acid concentration and both prevalent and incident hypertension; however, data regarding the influence of higher uric acid concentration at baseline on blood pressure control by antihypertensive drugs is scarce. Thus, a prospective cohort study was performed. The study outcome was the non-attainment of optimal blood pressure (NOBP). NOBP level was defined according to the Japanese hypertension guideline. This study enrolled a Japanese community-based cohort (N = 8,664; age 65.5 ± 6.4 years; women, 55.0%) who were not using antihypertensive drugs on the first visit for a health check-up program but started using antihypertensive drug(s) on the next-year visit. The participants were classified into quartiles based basic uric acid concenPloS oneHigher baseline uric acid concentration is associated with non-attainment of optimal blood pressure.PMC7384644JP17ek0310005, JP18ek0310010, JP19ek0310010 and JP18lk1010033H20-Junkankitou (Seishu)・Ippan-008 and H24-Nanchitou (Jin)・Ippan-006Kasahara MIseki KAsahi KWatanabe TFujimoto SKonta TTsuruya KSato YYamagata KShibagaki YMoriyama TKondo MNarita IfalseHigher baseline uric acid concentration is associated with non-attainment of optimal blood pressure.A significant relationship exists between elevated uric acid concentration and both prevalent and incident hypertension; however, data regarding the influence of higher uric acid concentration at baseline on blood pressure control by antihypertensive drugs is scarce. Thus, a prospective cohort study was performed. The study outcome was the non-attainment of optimal blood pressure (NOBP). NOBP level was defined according to the Japanese hypertension guideline. This study enrolled a Japanese community-based cohort (N = 8,664; age 65.5 ± 6.4 years; women, 55.0%) who were not using antihypertensive drugs on the first visit for a health check-up program but started using antihypertensive drug(s) on the next-year visit. The participants were classified into quartiles based basic uric acid concen2020-01-01T00:00:00Z20202025-04-21T17:58:00.932Z2025-04-05T17:03:23.926ZS-EPMC73846443271697710.1371/journal.pone.0236602