{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aoki T"],"funding":["Japan Society for the Promotion of Science London","Japanese Leukemia Research Fund","Masato Kawano Memorial Public Interest Foundation for Promotion of Pediatrics","Chiba University","Japan Society for the Promotion of Science"],"pagination":["2223-2233"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7385353"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111(7)"],"pubmed_abstract":["Invariant natural killer T (iNKT) cells are innate-like CD1d-restricted T cells that express the invariant T cell receptor (TCR) composed of Vα24 and Vβ11 in humans. iNKT cells specifically recognize glycolipid antigens such as α-galactosylceramide (αGalCer) presented by CD1d. iNKT cells show direct cytotoxicity toward CD1d-positive tumor cells, especially when CD1d presents glycolipid antigens. However, iNKT cell recognition of CD1d-negative tumor cells is unknown, and direct cytotoxicity of iNKT cells toward CD1d-negative tumor cells remains controversial. Here, we demonstrate that activated iNKT cells recognize leukemia cells in a CD1d-independent manner, however still in a TCR-mediated way. iNKT cells degranulated and released Th1 cytokines toward CD1d-negative leukemia cells (K562, HL"],"journal":["Cancer science"],"pubmed_title":["Activated invariant natural killer T cells directly recognize leukemia cells in a CD1d-independent manner."],"pmcid":["PMC7385353"],"funding_grant_id":["Therapeutics Research Initiative Grant/2018-Y7,","Therapeutics Research Initiative Grant/2018‐Y7,","Research award for young researchers","KAKENHI/18K16108"],"pubmed_authors":["Hara A","Takatani T","Motoyoshi K","Kiuchi M","Motohashi S","Shimojo N","Ishii A","Takami M","Nakayama T","Hino M","Aoki T","Toyoda T","Okada R","Hirahara K","Koyama-Nasu R","Kimura MY"],"additional_accession":[]},"is_claimable":false,"name":"Activated invariant natural killer T cells directly recognize leukemia cells in a CD1d-independent manner.","description":"Invariant natural killer T (iNKT) cells are innate-like CD1d-restricted T cells that express the invariant T cell receptor (TCR) composed of Vα24 and Vβ11 in humans. iNKT cells specifically recognize glycolipid antigens such as α-galactosylceramide (αGalCer) presented by CD1d. iNKT cells show direct cytotoxicity toward CD1d-positive tumor cells, especially when CD1d presents glycolipid antigens. However, iNKT cell recognition of CD1d-negative tumor cells is unknown, and direct cytotoxicity of iNKT cells toward CD1d-negative tumor cells remains controversial. Here, we demonstrate that activated iNKT cells recognize leukemia cells in a CD1d-independent manner, however still in a TCR-mediated way. iNKT cells degranulated and released Th1 cytokines toward CD1d-negative leukemia cells (K562, HL","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-04T07:40:40.188Z","creation":"2025-04-04T07:40:40.188Z"},"accession":"S-EPMC7385353","cross_references":{"pubmed":["32324315"],"doi":["10.1111/cas.14428"]}}