{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Agius JE"],"funding":["Australia and Pacific Science Foundation","Holsworth Wildlife Research Endowment"],"pagination":["100116"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7386737"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were determined following oral administration in 21 Asian house geckos (<i>Hemidactylus frenatus</i>) at a dose of 10 mg/kg. Changes in enrofloxacin and ciprofloxacin plasma concentrations were quantified at regular intervals over 72 h (1, 2, 6, 12, 24, 48, and 72 h). Samples were analysed by high-pressure liquid chromatography (HPLC) and the enrofloxacin pharmacokinetic data underwent a two-compartment analysis. Due to the limited ciprofloxacin plasma concentrations above the lower limit of quantification (LLOQ), the ciprofloxacin data underwent non-compartment analysis and the half-life was determined by the Lineweaver-Burke plot and analysis. The enrofloxacin and ciprofloxacin mean half-lives (<i>t</i> <sub>½</"],"journal":["Veterinary and animal science"],"pubmed_title":["Pharmacokinetic profile of enrofloxacin and its metabolite ciprofloxacin in Asian house geckos (<i>Hemidactylus frenatus</i>) after single-dose oral administration of enrofloxacin."],"pmcid":["PMC7386737"],"funding_grant_id":["G200647","APSF 17/6"],"pubmed_authors":["Kimble B","Govendir M","Rose K","Phalen DN","Agius JE","Pollard CL"],"additional_accession":[]},"is_claimable":false,"name":"Pharmacokinetic profile of enrofloxacin and its metabolite ciprofloxacin in Asian house geckos (<i>Hemidactylus frenatus</i>) after single-dose oral administration of enrofloxacin.","description":"The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were determined following oral administration in 21 Asian house geckos (<i>Hemidactylus frenatus</i>) at a dose of 10 mg/kg. Changes in enrofloxacin and ciprofloxacin plasma concentrations were quantified at regular intervals over 72 h (1, 2, 6, 12, 24, 48, and 72 h). Samples were analysed by high-pressure liquid chromatography (HPLC) and the enrofloxacin pharmacokinetic data underwent a two-compartment analysis. Due to the limited ciprofloxacin plasma concentrations above the lower limit of quantification (LLOQ), the ciprofloxacin data underwent non-compartment analysis and the half-life was determined by the Lineweaver-Burke plot and analysis. The enrofloxacin and ciprofloxacin mean half-lives (<i>t</i> <sub>½</","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-19T23:03:16.297Z","creation":"2025-04-19T23:03:16.297Z"},"accession":"S-EPMC7386737","cross_references":{"pubmed":["32734117"],"doi":["10.1016/j.vas.2020.100116"]}}