biostudies-literatureAgius JEAustralia and Pacific Science FoundationHolsworth Wildlife Research Endowment100116https://www.ebi.ac.uk/biostudies/studies/S-EPMC7386737biostudies-literatureUnknown9The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were determined following oral administration in 21 Asian house geckos (<i>Hemidactylus frenatus</i>) at a dose of 10 mg/kg. Changes in enrofloxacin and ciprofloxacin plasma concentrations were quantified at regular intervals over 72 h (1, 2, 6, 12, 24, 48, and 72 h). Samples were analysed by high-pressure liquid chromatography (HPLC) and the enrofloxacin pharmacokinetic data underwent a two-compartment analysis. Due to the limited ciprofloxacin plasma concentrations above the lower limit of quantification (LLOQ), the ciprofloxacin data underwent non-compartment analysis and the half-life was determined by the Lineweaver-Burke plot and analysis. The enrofloxacin and ciprofloxacin mean half-lives (<i>t</i> <sub>½</Veterinary and animal sciencePharmacokinetic profile of enrofloxacin and its metabolite ciprofloxacin in Asian house geckos (<i>Hemidactylus frenatus</i>) after single-dose oral administration of enrofloxacin.PMC7386737G200647APSF 17/6Kimble BGovendir MRose KPhalen DNAgius JEPollard CLfalsePharmacokinetic profile of enrofloxacin and its metabolite ciprofloxacin in Asian house geckos (<i>Hemidactylus frenatus</i>) after single-dose oral administration of enrofloxacin.The pharmacokinetics of enrofloxacin and its active metabolite ciprofloxacin were determined following oral administration in 21 Asian house geckos (<i>Hemidactylus frenatus</i>) at a dose of 10 mg/kg. Changes in enrofloxacin and ciprofloxacin plasma concentrations were quantified at regular intervals over 72 h (1, 2, 6, 12, 24, 48, and 72 h). Samples were analysed by high-pressure liquid chromatography (HPLC) and the enrofloxacin pharmacokinetic data underwent a two-compartment analysis. Due to the limited ciprofloxacin plasma concentrations above the lower limit of quantification (LLOQ), the ciprofloxacin data underwent non-compartment analysis and the half-life was determined by the Lineweaver-Burke plot and analysis. The enrofloxacin and ciprofloxacin mean half-lives (<i>t</i> <sub>½</2020-01-01T00:00:00Z2020 Jun2025-04-19T23:03:16.297Z2025-04-19T23:03:16.297ZS-EPMC73867373273411710.1016/j.vas.2020.100116