{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["36(6)"],"submitter":["Zhao F"],"pubmed_abstract":["In tissue engineering experiments in vitro, bioreactors have been used for applying wall shear stress (WSS) on cells to regulate cellular activities. To determine the loading conditions within bioreactors and to design tissue engineering products, in silico models are used. Previous in silico studies in bone tissue engineering (BTE) focused on quantifying the WSS on cells and the influence on appositional tissue growth. However, many BTE experiments also show interstitial tissue formation (i.e., tissue infiltrated in the pores rather than growing on the struts - appositional growth), which has not been considered in previous in silico studies. We hereby used a multiscale fluid-solid interaction model to quantify the WSS and mechanical strain on cells with interstitial tissue formation, tak"],"journal":["International journal for numerical methods in biomedical engineering"],"pagination":["e3342"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7388075"],"repository":["biostudies-literature"],"pubmed_title":["Fluid flow-induced cell stimulation in bone tissue engineering changes due to interstitial tissue formation in vitro."],"pmcid":["PMC7388075"],"pubmed_authors":["Ito K","Zhao F","Hofmann S","van Rietbergen B"],"additional_accession":[]},"is_claimable":false,"name":"Fluid flow-induced cell stimulation in bone tissue engineering changes due to interstitial tissue formation in vitro.","description":"In tissue engineering experiments in vitro, bioreactors have been used for applying wall shear stress (WSS) on cells to regulate cellular activities. To determine the loading conditions within bioreactors and to design tissue engineering products, in silico models are used. Previous in silico studies in bone tissue engineering (BTE) focused on quantifying the WSS on cells and the influence on appositional tissue growth. However, many BTE experiments also show interstitial tissue formation (i.e., tissue infiltrated in the pores rather than growing on the struts - appositional growth), which has not been considered in previous in silico studies. We hereby used a multiscale fluid-solid interaction model to quantify the WSS and mechanical strain on cells with interstitial tissue formation, tak","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-05T15:19:44.188Z","creation":"2025-04-05T15:19:44.188Z"},"accession":"S-EPMC7388075","cross_references":{"pubmed":["32323478"],"doi":["10.1002/cnm.3342"]}}