{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(2)"],"submitter":["Zhao M"],"pubmed_abstract":["Osteosarcoma (OS) is the most common primary malignant bone tumor in pediatric and adolescent patients. The calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) performs an essential function in cell proliferation and apoptosis. The present study investigated the effect of CacyBP/SIP in OS cell proliferation and apoptosis. CacyBP/SIP mRNA expression levels were evaluated in four OS cell lines by quantitative PCR. CacyBP/SIP expression was downregulated in Saos-2 cells using a lentivirus transfection system and the transfection efficiency was analyzed. The effects of CacyBP/SIP downregulation on Saos-2 cell proliferation and colony-formation ability were evaluated by MTT and colony-formation assays. The effect of CacyBP/SIP knockdown on Saos-2 cell cycle and apoptosis was analy"],"journal":["Experimental and therapeutic medicine"],"pagination":["1397-1404"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7388306"],"repository":["biostudies-literature"],"pubmed_title":["CacyBP/SIP promotes tumor progression by regulating apoptosis and arresting the cell cycle in osteosarcoma."],"pmcid":["PMC7388306"],"pubmed_authors":["Zhao M","Zhang GC","Chen HY","Zhang RZ","Qi DW"],"additional_accession":[]},"is_claimable":false,"name":"CacyBP/SIP promotes tumor progression by regulating apoptosis and arresting the cell cycle in osteosarcoma.","description":"Osteosarcoma (OS) is the most common primary malignant bone tumor in pediatric and adolescent patients. The calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) performs an essential function in cell proliferation and apoptosis. The present study investigated the effect of CacyBP/SIP in OS cell proliferation and apoptosis. CacyBP/SIP mRNA expression levels were evaluated in four OS cell lines by quantitative PCR. CacyBP/SIP expression was downregulated in Saos-2 cells using a lentivirus transfection system and the transfection efficiency was analyzed. The effects of CacyBP/SIP downregulation on Saos-2 cell proliferation and colony-formation ability were evaluated by MTT and colony-formation assays. The effect of CacyBP/SIP knockdown on Saos-2 cell cycle and apoptosis was analy","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2025-04-05T15:20:05.732Z","creation":"2025-04-05T15:20:05.732Z"},"accession":"S-EPMC7388306","cross_references":{"pubmed":["32742374"],"doi":["10.3892/etm.2020.8843"]}}