{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Parida R"],"funding":["Council of Scientific and Industrial Research"],"pagination":["100002"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7388392"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1"],"pubmed_abstract":["Autoantibody production is one of the leading factors of immune infertility, an autoimmune disease of the male reproductive system. The potential involvement of MHC-class II derived self-peptides against bacterial proteins in the antisperm antibody (ASA) production has been reported previously. Apparently, <i>Streptococcus agalactiae</i> has been considered as an important pathogen to impart infection-induced infertility in a bacteriospermia associated leukocytospermia (LCS/BS) state. Hence, the present study attempts to confirm <i>S. agalactiae</i> specific Laminin binding protein (Lmb) derived self-peptide ('<b>KDSYTKKAKAFKKEA')</b> namely human Motile Sperm domain-containing protein 2 (MOSPD2) as an auto-antigen in LCS/BS condition. Semen samples were collected from infertile men with L"],"journal":["Journal of translational autoimmunity"],"pubmed_title":["Human MOSPD2: A bacterial Lmb mimicked auto-antigen is involved in immune infertility."],"pmcid":["PMC7388392"],"funding_grant_id":["09/1036/0005/2016 EMR-I"],"pubmed_authors":["Parida R"],"additional_accession":[]},"is_claimable":false,"name":"Human MOSPD2: A bacterial Lmb mimicked auto-antigen is involved in immune infertility.","description":"Autoantibody production is one of the leading factors of immune infertility, an autoimmune disease of the male reproductive system. The potential involvement of MHC-class II derived self-peptides against bacterial proteins in the antisperm antibody (ASA) production has been reported previously. Apparently, <i>Streptococcus agalactiae</i> has been considered as an important pathogen to impart infection-induced infertility in a bacteriospermia associated leukocytospermia (LCS/BS) state. Hence, the present study attempts to confirm <i>S. agalactiae</i> specific Laminin binding protein (Lmb) derived self-peptide ('<b>KDSYTKKAKAFKKEA')</b> namely human Motile Sperm domain-containing protein 2 (MOSPD2) as an auto-antigen in LCS/BS condition. Semen samples were collected from infertile men with L","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2026-05-04T23:42:00.331Z","creation":"2020-11-19T13:36:40Z"},"accession":"S-EPMC7388392","cross_references":{"pubmed":["32743492"],"doi":["10.1016/j.jtauto.2019.100002"]}}