biostudies-literatureParida RCouncil of Scientific and Industrial Research100002https://www.ebi.ac.uk/biostudies/studies/S-EPMC7388392biostudies-literatureUnknown1Autoantibody production is one of the leading factors of immune infertility, an autoimmune disease of the male reproductive system. The potential involvement of MHC-class II derived self-peptides against bacterial proteins in the antisperm antibody (ASA) production has been reported previously. Apparently, <i>Streptococcus agalactiae</i> has been considered as an important pathogen to impart infection-induced infertility in a bacteriospermia associated leukocytospermia (LCS/BS) state. Hence, the present study attempts to confirm <i>S. agalactiae</i> specific Laminin binding protein (Lmb) derived self-peptide ('<b>KDSYTKKAKAFKKEA')</b> namely human Motile Sperm domain-containing protein 2 (MOSPD2) as an auto-antigen in LCS/BS condition. Semen samples were collected from infertile men with LJournal of translational autoimmunityHuman MOSPD2: A bacterial Lmb mimicked auto-antigen is involved in immune infertility.PMC738839209/1036/0005/2016 EMR-IParida RfalseHuman MOSPD2: A bacterial Lmb mimicked auto-antigen is involved in immune infertility.Autoantibody production is one of the leading factors of immune infertility, an autoimmune disease of the male reproductive system. The potential involvement of MHC-class II derived self-peptides against bacterial proteins in the antisperm antibody (ASA) production has been reported previously. Apparently, <i>Streptococcus agalactiae</i> has been considered as an important pathogen to impart infection-induced infertility in a bacteriospermia associated leukocytospermia (LCS/BS) state. Hence, the present study attempts to confirm <i>S. agalactiae</i> specific Laminin binding protein (Lmb) derived self-peptide ('<b>KDSYTKKAKAFKKEA')</b> namely human Motile Sperm domain-containing protein 2 (MOSPD2) as an auto-antigen in LCS/BS condition. Semen samples were collected from infertile men with L2019-01-01T00:00:00Z2019 Apr2026-05-04T23:42:00.331Z2020-11-19T13:36:40ZS-EPMC73883923274349210.1016/j.jtauto.2019.100002