{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chu Y"],"funding":["Clinical Technology Development Foundation of Jiangsu University","Jiangsu Government Scholarship for Overseas Studies","Foundation of the Science and Technology Project of Wujin","Foundation of the Youth Science and Technology Project of Changzhou Health and Family Planning Commission","Changzhou High-Level Medical Talents Training Project","Special Fund for Clinical Medicine of Jiangsu University","Innovative and Entrepreneurial Plan of Jiangsu Province"],"pagination":["227"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7388529"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Background</h4>Wogonin, a natural flavonoid-like chemical compound, exhibits anti-inflammatory, antitumor, antiviral, neuroprotective, and anxiolytic effects by modulating a variety of cellular signaling pathways including PI3K-Akt, p53, nuclear factor κB (NF-κB), mitogen-activated protein kinase (MAPK) pathways. In this study, its antiviral effect against herpes simplex virus (HSV) type 1 and 2 (HSV-1 and HSV-2) replication was investigated.<h4>Results</h4>Wogonin suppressed HSV-2-induced cytopathic effect (CPE) and reduced viral mRNA transcription, viral protein synthesis, and infectious virion particle titers in a dose-dependent manner. A time-of-drug-addition assay demonstrated that wogonin acted as a postentry viral inhibitor. Wogonin also significantly reduced HSV-induced NF-κB a"],"journal":["BMC microbiology"],"pubmed_title":["Wogonin inhibits in vitro herpes simplex virus type 1 and 2 infection by modulating cellular NF-κB and MAPK pathways."],"pmcid":["PMC7388529"],"funding_grant_id":["WS201402","WS201710","QN201505","JDLC2X020","JLY20160038","2016CZBJ060"],"pubmed_authors":["Xu L","Yun Z","Wu Z","Su A","Lv X","Fu X","Chu Y","Song S","Zhang L","Wang Y","Chen D"],"additional_accession":[]},"is_claimable":false,"name":"Wogonin inhibits in vitro herpes simplex virus type 1 and 2 infection by modulating cellular NF-κB and MAPK pathways.","description":"<h4>Background</h4>Wogonin, a natural flavonoid-like chemical compound, exhibits anti-inflammatory, antitumor, antiviral, neuroprotective, and anxiolytic effects by modulating a variety of cellular signaling pathways including PI3K-Akt, p53, nuclear factor κB (NF-κB), mitogen-activated protein kinase (MAPK) pathways. In this study, its antiviral effect against herpes simplex virus (HSV) type 1 and 2 (HSV-1 and HSV-2) replication was investigated.<h4>Results</h4>Wogonin suppressed HSV-2-induced cytopathic effect (CPE) and reduced viral mRNA transcription, viral protein synthesis, and infectious virion particle titers in a dose-dependent manner. A time-of-drug-addition assay demonstrated that wogonin acted as a postentry viral inhibitor. Wogonin also significantly reduced HSV-induced NF-κB a","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-05T15:21:14.57Z","creation":"2024-11-15T16:29:38.669Z"},"accession":"S-EPMC7388529","cross_references":{"pubmed":["32723300"],"doi":["10.1186/s12866-020-01916-2"]}}