biostudies-literatureUnknown15(7)Frazao DR<h4>Background</h4>Periodontitis is a multifactorial inflammatory disease of tooth supporting tissues caused by oral biofilms, influenced by environmental and genetic factors, among others. Ethanol consumption has been considered a factor that enhances alveolar bone loss, especially in high doses. The present study aims to investigate the changes promoted by ethanol binge drinking per se or associated with ligature-induced periodontal breakdown on alveolar bone loss.<h4>Materials and methods</h4>Thirty-two Wistar rats were randomly allocated into four groups: control (C), ethanol (3g/kg/day; 3 days On-4 days Off protocol by gavage for 28 days, EtOH), experimental periodontitis (EP) and experimental periodontitis plus ethanol administration (EP+EtOH). On day 14th, periodontitis was induced PloS onee0236161https://www.ebi.ac.uk/biostudies/studies/S-EPMC7392256biostudies-literatureEthanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis.PMC7392256Monteiro DMartins MDCollares FMMaia CDSFRosing CKFrazao DRFerreira ROLima RRChemelo VDSBalbinot GSBittencourt LOfalseEthanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis.<h4>Background</h4>Periodontitis is a multifactorial inflammatory disease of tooth supporting tissues caused by oral biofilms, influenced by environmental and genetic factors, among others. Ethanol consumption has been considered a factor that enhances alveolar bone loss, especially in high doses. The present study aims to investigate the changes promoted by ethanol binge drinking per se or associated with ligature-induced periodontal breakdown on alveolar bone loss.<h4>Materials and methods</h4>Thirty-two Wistar rats were randomly allocated into four groups: control (C), ethanol (3g/kg/day; 3 days On-4 days Off protocol by gavage for 28 days, EtOH), experimental periodontitis (EP) and experimental periodontitis plus ethanol administration (EP+EtOH). On day 14th, periodontitis was induced 2020-01-01T00:00:00Z20202025-04-25T18:34:22.871Z2025-04-06T07:37:49.497ZS-EPMC73922563273026910.1371/journal.pone.0236161