{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li K"],"funding":["Key Research and Development Program of Shaanxi"],"pagination":["585-595"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7395032"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(4)"],"pubmed_abstract":["<h4>Purpose</h4>Immune function imbalance is closely associated with the occurrence and development of infectious diseases. We studied the characteristics of changes in T-lymphocyte subsets and their risk factors in HIV-negative patients with active tuberculosis (ATB).<h4>Methods</h4>T-lymphocyte subsets in 275 HIV-negative ATB patients were quantitatively analyzed and compared with an Mycobacteriumtuberculosis-free control group. Single-factor and multifactor analyses of clinical and laboratory characteristics of patients were also conducted.<h4>Results</h4>In ATB patients, CD4 and CD8 T-cell counts decreased, and the levels were positively interrelated (r = 0.655, P < 0.0001). After 4 weeks of antituberculosis treatment, CD4 and CD8 T-cell counts increased significantly but remained lowe"],"journal":["Infection"],"pubmed_title":["Changes in T-lymphocyte subsets and risk factors in human immunodeficiency virus-negative patients with active tuberculosis."],"pmcid":["PMC7395032"],"funding_grant_id":["2020SF-113"],"pubmed_authors":["Ran R","Jiang Z","Li T","Li K","Fan C","Yin Z"],"additional_accession":[]},"is_claimable":false,"name":"Changes in T-lymphocyte subsets and risk factors in human immunodeficiency virus-negative patients with active tuberculosis.","description":"<h4>Purpose</h4>Immune function imbalance is closely associated with the occurrence and development of infectious diseases. We studied the characteristics of changes in T-lymphocyte subsets and their risk factors in HIV-negative patients with active tuberculosis (ATB).<h4>Methods</h4>T-lymphocyte subsets in 275 HIV-negative ATB patients were quantitatively analyzed and compared with an Mycobacteriumtuberculosis-free control group. Single-factor and multifactor analyses of clinical and laboratory characteristics of patients were also conducted.<h4>Results</h4>In ATB patients, CD4 and CD8 T-cell counts decreased, and the levels were positively interrelated (r = 0.655, P < 0.0001). After 4 weeks of antituberculosis treatment, CD4 and CD8 T-cell counts increased significantly but remained lowe","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2025-04-18T14:42:31.247Z","creation":"2025-04-07T00:54:36.738Z"},"accession":"S-EPMC7395032","cross_references":{"pubmed":["32472529"],"doi":["10.1007/s15010-020-01451-2"]}}