biostudies-literatureLi KKey Research and Development Program of Shaanxi585-595https://www.ebi.ac.uk/biostudies/studies/S-EPMC7395032biostudies-literatureUnknown48(4)<h4>Purpose</h4>Immune function imbalance is closely associated with the occurrence and development of infectious diseases. We studied the characteristics of changes in T-lymphocyte subsets and their risk factors in HIV-negative patients with active tuberculosis (ATB).<h4>Methods</h4>T-lymphocyte subsets in 275 HIV-negative ATB patients were quantitatively analyzed and compared with an Mycobacteriumtuberculosis-free control group. Single-factor and multifactor analyses of clinical and laboratory characteristics of patients were also conducted.<h4>Results</h4>In ATB patients, CD4 and CD8 T-cell counts decreased, and the levels were positively interrelated (r = 0.655, P < 0.0001). After 4 weeks of antituberculosis treatment, CD4 and CD8 T-cell counts increased significantly but remained loweInfectionChanges in T-lymphocyte subsets and risk factors in human immunodeficiency virus-negative patients with active tuberculosis.PMC73950322020SF-113Ran RJiang ZLi TLi KFan CYin ZfalseChanges in T-lymphocyte subsets and risk factors in human immunodeficiency virus-negative patients with active tuberculosis.<h4>Purpose</h4>Immune function imbalance is closely associated with the occurrence and development of infectious diseases. We studied the characteristics of changes in T-lymphocyte subsets and their risk factors in HIV-negative patients with active tuberculosis (ATB).<h4>Methods</h4>T-lymphocyte subsets in 275 HIV-negative ATB patients were quantitatively analyzed and compared with an Mycobacteriumtuberculosis-free control group. Single-factor and multifactor analyses of clinical and laboratory characteristics of patients were also conducted.<h4>Results</h4>In ATB patients, CD4 and CD8 T-cell counts decreased, and the levels were positively interrelated (r = 0.655, P < 0.0001). After 4 weeks of antituberculosis treatment, CD4 and CD8 T-cell counts increased significantly but remained lowe2020-01-01T00:00:00Z2020 Aug2025-04-18T14:42:31.247Z2025-04-07T00:54:36.738ZS-EPMC73950323247252910.1007/s15010-020-01451-2