{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kecskemeti S"],"funding":["Department of Radiology, University of Wisconsin-Madison","Eunice Kennedy Shriver National Institute of Child Health and Human Development","NICHD NIH HHS","NIA NIH HHS","NIDA NIH HHS","NIMH NIH HHS","National Institutes of Health"],"pagination":["2400-2411"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7396302"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["84(5)"],"pubmed_abstract":["<h4>Purpose</h4>To test the performance of the MPnRAGE motion-correction algorithm on quantitative relaxometry estimates.<h4>Methods</h4>Twelve children (9.4 ± 2.6 years, min = 6.5 years, max = 13.8 years) were imaged 3 times in a session without sedation. Stabilization padding was not used for the second and third scans. Quantitative T<sub>1</sub> values were estimated in each voxel on images reconstructed with and without motion correction. Mean T<sub>1</sub> values were assessed in various regions determined from automated segmentation algorithms. Statistical tests were performed on mean values and the coefficient of variation across the measurements. Accuracy of T<sub>1</sub> estimates were determined by scanning the High Precision Devices (Boulder, CO) MRI system phantom with the same protocol.<h4>Results</h4>The T<sub>1</sub> values obtained with MPnRAGE agreed within 4% of the reference values of the High Precision Devices phantom. The best fit line was T<sub>1</sub> (MPnRAGE) = 1.02 T<sub>1</sub> (reference)-0.9 ms, R<sup>2</sup>  = 0.9999. For in vivo studies, motion correction reduced the coefficients of variation of mean T<sub>1</sub> values in whole-brain tissue regions determined by FSL FAST by 74% ± 7%, and subcortical regions determined by FIRST and FreeSurfer by 32% ± 21% and 33% ± 26%, respectively. Across all participants, the mean coefficients of variation ranged from 0.8% to 2.0% for subcortical regions and 0.6% ± 0.5% for cortical regions when motion correction was applied.<h4>Conclusion</h4>The MPnRAGE technique demonstrated highly accurate values in phantom measurements. When combined with retrospective motion correction, MPnRAGE demonstrated highly reproducible T<sub>1</sub> values, even in participants who moved during the acquisition."],"journal":["Magnetic resonance in medicine"],"pubmed_title":["Three-dimensional motion-corrected T<sub>1</sub> relaxometry with MPnRAGE."],"pmcid":["PMC7396302"],"funding_grant_id":["AG051216","IDDRC U54 HD090256","UF1 AG051216","R01 AG037639","DA050258","R01 MH097464","R34 DA050258","MH100031","HD094715","P50 MH100031","AG15001","U01 AG051406","R01 MH101504","MH101504","U54 HD090256","R01 HD094715","MH097464"],"pubmed_authors":["Kecskemeti S","Alexander AL"],"additional_accession":[]},"is_claimable":false,"name":"Three-dimensional motion-corrected T<sub>1</sub> relaxometry with MPnRAGE.","description":"<h4>Purpose</h4>To test the performance of the MPnRAGE motion-correction algorithm on quantitative relaxometry estimates.<h4>Methods</h4>Twelve children (9.4 ± 2.6 years, min = 6.5 years, max = 13.8 years) were imaged 3 times in a session without sedation. Stabilization padding was not used for the second and third scans. Quantitative T<sub>1</sub> values were estimated in each voxel on images reconstructed with and without motion correction. Mean T<sub>1</sub> values were assessed in various regions determined from automated segmentation algorithms. Statistical tests were performed on mean values and the coefficient of variation across the measurements. Accuracy of T<sub>1</sub> estimates were determined by scanning the High Precision Devices (Boulder, CO) MRI system phantom with the same protocol.<h4>Results</h4>The T<sub>1</sub> values obtained with MPnRAGE agreed within 4% of the reference values of the High Precision Devices phantom. The best fit line was T<sub>1</sub> (MPnRAGE) = 1.02 T<sub>1</sub> (reference)-0.9 ms, R<sup>2</sup>  = 0.9999. For in vivo studies, motion correction reduced the coefficients of variation of mean T<sub>1</sub> values in whole-brain tissue regions determined by FSL FAST by 74% ± 7%, and subcortical regions determined by FIRST and FreeSurfer by 32% ± 21% and 33% ± 26%, respectively. Across all participants, the mean coefficients of variation ranged from 0.8% to 2.0% for subcortical regions and 0.6% ± 0.5% for cortical regions when motion correction was applied.<h4>Conclusion</h4>The MPnRAGE technique demonstrated highly accurate values in phantom measurements. When combined with retrospective motion correction, MPnRAGE demonstrated highly reproducible T<sub>1</sub> values, even in participants who moved during the acquisition.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-04T21:57:36.048Z","creation":"2022-02-11T12:15:17.564Z"},"accession":"S-EPMC7396302","cross_references":{"pubmed":["32301173"],"doi":["10.1002/mrm.28283"]}}