biostudies-literaturePikun NVState Education Development Agency Republic of LatviaE3143https://www.ebi.ac.uk/biostudies/studies/S-EPMC7397266biostudies-literatureUnknown25(14)New fluorinated 3,6-dihydropyridines were obtained by the electrophilic fluorination of 1,2-dihydropyridines with Selectfluor®. These 3-fluoro-3,6-dihydropyridines were easily converted to corresponding pyridines by the elimination of hydrogen fluoride under mild conditions. A new approach to the synthesis of methyl 2-(fluoromethyl)-5-nitro-6-arylnicotinates by the fluorination of 3-fluoro-2-methyl-5-nitro-3,6-dihydropyridines or 1,2-dihydropyridines with Selectfluor® has been developed.Molecules (Basel, Switzerland)Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor®.PMC7397266PostDoc project Nr.1.1.1.2/VIAA/2/18/373Vigante BPetrova MSobolev APajuste KPikun NVPlotniece AShermolovich YGMuhamadejev RRucins MfalseSynthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor®.New fluorinated 3,6-dihydropyridines were obtained by the electrophilic fluorination of 1,2-dihydropyridines with Selectfluor®. These 3-fluoro-3,6-dihydropyridines were easily converted to corresponding pyridines by the elimination of hydrogen fluoride under mild conditions. A new approach to the synthesis of methyl 2-(fluoromethyl)-5-nitro-6-arylnicotinates by the fluorination of 3-fluoro-2-methyl-5-nitro-3,6-dihydropyridines or 1,2-dihydropyridines with Selectfluor® has been developed.2020-01-01T00:00:00Z2020 Jul2025-04-04T08:20:06.709Z2025-04-04T08:20:06.709ZS-EPMC73972663266008510.3390/molecules25143143