{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kris-Etherton PM"],"funding":["National Center for Research Resources","NCRR NIH HHS","NIDDK NIH HHS","National Heart, Lung, and Blood Institute"],"pagination":["2089-2100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7398773"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["150(8)"],"pubmed_abstract":["Background
Factor VIIc, fibrinogen, and plasminogen activator inhibitor 1 (PAI-1) are cardiovascular disease (CVD) risk factors and are modulated, in part, by fat type and amount.Objective
We evaluated fat type and amount on the primary outcomes: factor VIIc, fibrinogen, and PAI-1.Methods
In the Dietary Effects on Lipoproteins and Thrombogenic Activity (DELTA) Trial, 2 controlled crossover feeding studies evaluated substituting carbohydrate or MUFAs for SFAs. Study 1: healthy participants (n = 103) were provided with (8 wk) an average American diet [AAD; designed to provide 37% of energy (%E) as fat, 16% SFA], a Step 1 diet (30%E fat, 9% SFA), and a diet low in SFA (Low-Sat; 26%E fat, 5% SFA). Study 2: participants (n = 85) at risk for CVD and metabolic syndrome (Me"],"journal":["The Journal of nutrition"],"pubmed_title":["The Type and Amount of Dietary Fat Affect Plasma Factor VIIc, Fibrinogen, and PAI-1 in Healthy Individuals and Individuals at High Cardiovascular Disease Risk: 2 Randomized Controlled Trials."],"pmcid":["PMC7398773"],"funding_grant_id":["MO1-RR00645","49649","49648","49659","P30 DK072476","M01 RR000645","M01 RR000400","49651","5-U01-HL49644","MO1-RR00400"],"pubmed_authors":["Miles M","Lefevre M","Williams B","Stewart K","Elmer PJ","Champagne CM","Martin L","Pearson TA","Tracy RP","Blackwell S","Bryan H","Slavin J","Stewart PW","Smiciklas-Wright H","Jacobs D","Brock R","Ramakrishnan R","Ryan D","Holleran SF","Chen NT","Derr J","Yu S","Mastro AM","Guinard JX","Reed R","Ginsberg HN","Cornell E","Farhat-Wood A","Ershow AG","Meaker K","Ngai C","Bodin D","Wold C","Proschan M","Sigman-Grant M","Stennett K","Towolawai T","York D","Cooper AD","Stewart P","Beecher G","Ginsberg H","Foley M","Leu SY","Goodwin T","Champagne C","Mustad V","Berglund L","Chirgwin K","Pearson T","Ershow A","Mills E","Youngblood M","Folsom A","Fontenez N","Davis C","Kris-Etherton PM","Ganga L","Holeman R","Kennedy B","Most M","Reddy CC","DELTA Investigators","Elmer P","Tracy R","Holleran S","Jones J","Abolafia J","Myers M","Siddiqui M","Barkate M","Wehbie J","Rodriguez C","Tilley MA","Karmally W","Roheim PS","Hosking J","Sechevich P","Tulley R","Zien C","Van Heel N","Williamson D","Fritz K","McGee B","Holden J","Dennis BH","Johnson C","Phillips K","Useche N","Jonnalagadda S","Stewart WB","Rifkind B","Dennis B","Anderson N","Foust E","Gordon D","Kris-Etherton P"],"additional_accession":[]},"is_claimable":false,"name":"The Type and Amount of Dietary Fat Affect Plasma Factor VIIc, Fibrinogen, and PAI-1 in Healthy Individuals and Individuals at High Cardiovascular Disease Risk: 2 Randomized Controlled Trials.","description":"Background
Factor VIIc, fibrinogen, and plasminogen activator inhibitor 1 (PAI-1) are cardiovascular disease (CVD) risk factors and are modulated, in part, by fat type and amount.Objective
We evaluated fat type and amount on the primary outcomes: factor VIIc, fibrinogen, and PAI-1.Methods
In the Dietary Effects on Lipoproteins and Thrombogenic Activity (DELTA) Trial, 2 controlled crossover feeding studies evaluated substituting carbohydrate or MUFAs for SFAs. Study 1: healthy participants (n = 103) were provided with (8 wk) an average American diet [AAD; designed to provide 37% of energy (%E) as fat, 16% SFA], a Step 1 diet (30%E fat, 9% SFA), and a diet low in SFA (Low-Sat; 26%E fat, 5% SFA). Study 2: participants (n = 85) at risk for CVD and metabolic syndrome (Me","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2026-04-22T03:23:30.006Z","creation":"2022-02-11T01:29:45.047Z"},"accession":"S-EPMC7398773","cross_references":{"pubmed":["32492148"],"doi":["10.1093/jn/nxaa137"]}}