{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Riaz N"],"funding":["University Research Council, Aga Khan University"],"pubmed_abstract":["<b>Background:</b> Androgen receptor (AR) has emerged as a significant favorable prognostic indicator in estrogen receptor expressing (ER<sup>+</sup>) breast cancer (BCa); however, its clinical and biological relevance in triple negative breast cancer (TNBC) and association with cancer stem cell (CSC) markers remain ambiguous. <b>Methods:</b> We examined the immunohistochemical expression of AR in a cohort of stage I-III TNBC cases (<i>n</i> = 197) with a long-term clinical follow-up data (mean follow-up = 53.6 months). Significance of AR expression was correlated with prognostic biomarkers including cancer stem cell markers (CD44, CD24, and ALDH1), basal markers (CK5, CK14, and nestin), proliferation marker (ki-67), apoptotic marker (Bcl-2), and COX-2. Expression of CK5 and nestin was use"],"journal":["Frontiers in oncology"],"pagination":["1083"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7399239"],"repository":["biostudies-literature"],"pubmed_title":["Lack of Androgen Receptor Expression Selects for Basal-Like Phenotype and Is a Predictor of Poor Clinical Outcome in Non-Metastatic Triple Negative Breast Cancer."],"pmcid":["PMC7399239"],"pubmed_authors":["Idress R","Habib S","Riaz N","Lalani EN"],"additional_accession":[]},"is_claimable":false,"name":"Lack of Androgen Receptor Expression Selects for Basal-Like Phenotype and Is a Predictor of Poor Clinical Outcome in Non-Metastatic Triple Negative Breast Cancer.","description":"<b>Background:</b> Androgen receptor (AR) has emerged as a significant favorable prognostic indicator in estrogen receptor expressing (ER<sup>+</sup>) breast cancer (BCa); however, its clinical and biological relevance in triple negative breast cancer (TNBC) and association with cancer stem cell (CSC) markers remain ambiguous. <b>Methods:</b> We examined the immunohistochemical expression of AR in a cohort of stage I-III TNBC cases (<i>n</i> = 197) with a long-term clinical follow-up data (mean follow-up = 53.6 months). Significance of AR expression was correlated with prognostic biomarkers including cancer stem cell markers (CD44, CD24, and ALDH1), basal markers (CK5, CK14, and nestin), proliferation marker (ki-67), apoptotic marker (Bcl-2), and COX-2. Expression of CK5 and nestin was use","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-05-07T15:12:30.583Z","creation":"2020-08-31T07:09:08Z"},"accession":"S-EPMC7399239","cross_references":{"pubmed":["32850312"],"doi":["10.3389/fonc.2020.01083"]}}