biostudies-literatureZheng PFNational Natural Science Foundation of China13010https://www.ebi.ac.uk/biostudies/studies/S-EPMC7400760biostudies-literatureUnknown10(1)This research aimed to assess the associations of 7 parkin RBR E3 ubiquitin protein ligase (PRKN) and 4 parkin coregulated gene (PACRG) single-nucleotide polymorphisms (SNPs), their haplotypes, gene-gene (G × G) and gene-environment (G × E) interactions with hyperlipidaemia in the Chinese Maonan minority. The genotypes of the 11 SNPs in 912 normal and 736 hyperlipidaemic subjects were detected with next-generation sequencing technology. The genotypic and allelic frequencies of the rs1105056, rs10755582, rs2155510, rs9365344, rs11966842, rs6904305 and rs11966948 SNPs were different between the normal and hyperlipidaemic groups (P < 0.05-0.001). Correlations between the above 7 SNPs and blood lipid levels were also observed (P < 0.0045-0.001, P < 0.0045 was considered statistically significaScientific reportsAssociations of PRKN-PACRG SNPs and G × G and G × E interactions with the risk of hyperlipidaemia.PMC740076081460169Liu CXYin RXDeng GXWei BLGuan YZZheng PFfalseAssociations of PRKN-PACRG SNPs and G × G and G × E interactions with the risk of hyperlipidaemia.This research aimed to assess the associations of 7 parkin RBR E3 ubiquitin protein ligase (PRKN) and 4 parkin coregulated gene (PACRG) single-nucleotide polymorphisms (SNPs), their haplotypes, gene-gene (G × G) and gene-environment (G × E) interactions with hyperlipidaemia in the Chinese Maonan minority. The genotypes of the 11 SNPs in 912 normal and 736 hyperlipidaemic subjects were detected with next-generation sequencing technology. The genotypic and allelic frequencies of the rs1105056, rs10755582, rs2155510, rs9365344, rs11966842, rs6904305 and rs11966948 SNPs were different between the normal and hyperlipidaemic groups (P < 0.05-0.001). Correlations between the above 7 SNPs and blood lipid levels were also observed (P < 0.0045-0.001, P < 0.0045 was considered statistically significa2020-01-01T00:00:00Z2020 Aug2026-05-02T06:33:43.166Z2020-11-19T16:53:59ZS-EPMC74007603274762010.1038/s41598-020-68826-1