{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tsai YM"],"funding":["Ministry of Science and Technology, Taiwan"],"pagination":["E5081"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7404111"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(14)"],"pubmed_abstract":["For decades, lung cancer has been the leading cause of cancer-related death worldwide. Hypoxia-inducible factors (HIFs) play critical roles in mediating lung cancer development and metastasis. The present study aims to clarify how HIF's over-activation affects lung cancer angiogenesis not only in a normoxic condition, but also a hypoxic niche. Our study shows that human lung cancer exhibits elevated levels of ceruloplasmin (CP), which has a negative impact on the prognosis of patients. CP affects the cellular Fe2+ level, which inactivates prolyl hydroxylase (PHD) 1 and 2, resulting in HIF-2α enhancement. Increased HIF-2α leads to vascular endothelial growth factor-A (VEGF-A) secretion and angiogenesis. The expression of CP is under the epigenetic control of miR-145-5p. Restoration of miR-1"],"journal":["International journal of molecular sciences"],"pubmed_title":["Loss of miR-145-5p Causes Ceruloplasmin Interference with PHD-Iron Axis and HIF-2α Stabilization in Lung Adenocarcinoma-Mediated Angiogenesis."],"pmcid":["PMC7404111"],"funding_grant_id":["MOST107-2314-B-037-107-MY3; MOST 108-2320-B-037-024 -MY3; MOST 108-2314-B-037-094-; MOST 108-2314-B-037-095-; 107-2314-B-037-107-MY3"],"pubmed_authors":["Chang YY","Tsai YM","Lin YS","Jian SF","Chong IW","Wu KL","Huang YC","Hung JY","Tsai PH","Hsu YL","Chang WA"],"additional_accession":[]},"is_claimable":false,"name":"Loss of miR-145-5p Causes Ceruloplasmin Interference with PHD-Iron Axis and HIF-2α Stabilization in Lung Adenocarcinoma-Mediated Angiogenesis.","description":"For decades, lung cancer has been the leading cause of cancer-related death worldwide. Hypoxia-inducible factors (HIFs) play critical roles in mediating lung cancer development and metastasis. The present study aims to clarify how HIF's over-activation affects lung cancer angiogenesis not only in a normoxic condition, but also a hypoxic niche. Our study shows that human lung cancer exhibits elevated levels of ceruloplasmin (CP), which has a negative impact on the prognosis of patients. CP affects the cellular Fe2+ level, which inactivates prolyl hydroxylase (PHD) 1 and 2, resulting in HIF-2α enhancement. Increased HIF-2α leads to vascular endothelial growth factor-A (VEGF-A) secretion and angiogenesis. The expression of CP is under the epigenetic control of miR-145-5p. Restoration of miR-1","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-05-29T20:43:12.463Z","creation":"2025-05-29T20:43:12.463Z"},"accession":"S-EPMC7404111","cross_references":{"pubmed":["32708433"],"doi":["10.3390/ijms21145081"]}}