{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Azar P"],"funding":["French national Agency for Research on AIDS and Viral Hepatitis","Fondation Recherche Médicale","Sidaction","Conseil Régional Occitanie-Midi-Pyrénées"],"pagination":["136047"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7406249"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(12)"],"pubmed_abstract":["Type I IFN (IFN-I) production by plasmacytoid DCs (pDCs) occurs during acute HIV-1 infection in response to TLR7 stimulation, but the role of pDC-derived IFN-I in controlling or promoting HIV-1 infection is ambiguous. We report here a sex-biased interferogenic phenotype for a frequent single-nucleotide polymorphism of human TLR7, rs179008, displaying an impact on key parameters of acute HIV-1 infection. We show allele rs179008 T to determine lower TLR7 protein abundance in cells from women, specifically - likely by diminishing TLR7 mRNA translation efficiency through codon usage. The hypomorphic TLR7 phenotype is mirrored by decreased TLR7-driven IFN-I production by female pDCs. Among women from the French ANRS PRIMO cohort of acute HIV-1 patients, carriage of allele rs179008 T associated "],"journal":["JCI insight"],"pubmed_title":["TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women."],"pmcid":["PMC7406249"],"funding_grant_id":["DEQ20180339187","ECTZ22047","EP-53 study","BI25-2-02374","INSPIRE"],"pubmed_authors":["Passaes C","Cenac C","Meyer L","Shaiykova A","Muller-Trutwin M","Laffont S","Mejia JE","Essat A","Azar P","Delobel P","Youness A","Guery JC","Izopet J"],"additional_accession":[]},"is_claimable":false,"name":"TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women.","description":"Type I IFN (IFN-I) production by plasmacytoid DCs (pDCs) occurs during acute HIV-1 infection in response to TLR7 stimulation, but the role of pDC-derived IFN-I in controlling or promoting HIV-1 infection is ambiguous. We report here a sex-biased interferogenic phenotype for a frequent single-nucleotide polymorphism of human TLR7, rs179008, displaying an impact on key parameters of acute HIV-1 infection. We show allele rs179008 T to determine lower TLR7 protein abundance in cells from women, specifically - likely by diminishing TLR7 mRNA translation efficiency through codon usage. The hypomorphic TLR7 phenotype is mirrored by decreased TLR7-driven IFN-I production by female pDCs. Among women from the French ANRS PRIMO cohort of acute HIV-1 patients, carriage of allele rs179008 T associated ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2026-05-03T20:38:59.69Z","creation":"2020-11-19T13:32:36Z"},"accession":"S-EPMC7406249","cross_references":{"pubmed":["32554924"],"doi":["10.1172/jci.insight.136047"]}}