{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song Y"],"funding":["National Natural Science Foundation of China"],"pagination":["1880"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7412599"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["<i>Exophiala spinifera</i>, a capsule-producing black yeast, is overrepresented as agent of disseminated infection in humans with inherited dysfunction of the <i>CARD9</i> gene. In a review of published caspase recruitment domain-containing protein 9 (CARD9) deficiency cases, black fungi were linked to mutations other than those prevalent in yeast and dermatophyte cases, and were found to respond to a larger panel of cytokines. Here, we sequenced and annotated the genomes of BMU 08022 from a patient with CARD9 deficiency and two environmental strains, BMU 00051 and BMU 00047. We performed genomic and transcriptomic analysis for these isolates including published black yeasts genomes, using a combination of long-read (PACBIO) and short-read (Illumina) sequencing technologies with a hybrid a"],"journal":["Frontiers in microbiology"],"pubmed_title":["Comparative Analysis of Clinical and Environmental Strains of <i>Exophiala spinifera</i> by Long-Reads Sequencing and RNAseq Reveal Adaptive Strategies."],"pmcid":["PMC7412599"],"funding_grant_id":["31670145","81520108026"],"pubmed_authors":["Menezes da Silva N","Sybren de Hoog G","Li R","Vicente VA","Du M","Song Y","Yang E"],"additional_accession":[]},"is_claimable":false,"name":"Comparative Analysis of Clinical and Environmental Strains of <i>Exophiala spinifera</i> by Long-Reads Sequencing and RNAseq Reveal Adaptive Strategies.","description":"<i>Exophiala spinifera</i>, a capsule-producing black yeast, is overrepresented as agent of disseminated infection in humans with inherited dysfunction of the <i>CARD9</i> gene. In a review of published caspase recruitment domain-containing protein 9 (CARD9) deficiency cases, black fungi were linked to mutations other than those prevalent in yeast and dermatophyte cases, and were found to respond to a larger panel of cytokines. Here, we sequenced and annotated the genomes of BMU 08022 from a patient with CARD9 deficiency and two environmental strains, BMU 00051 and BMU 00047. We performed genomic and transcriptomic analysis for these isolates including published black yeasts genomes, using a combination of long-read (PACBIO) and short-read (Illumina) sequencing technologies with a hybrid a","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-04-08T00:37:10.575Z","creation":"2020-08-29T07:22:09Z"},"accession":"S-EPMC7412599","cross_references":{"pubmed":["32849462"],"doi":["10.3389/fmicb.2020.01880"]}}