{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pulido-Valdeolivas I"],"funding":["This study was supported by the Instituto de Salud Carlos III, Spain and Fondo Europeo de Desarrollo Regional"],"pagination":["13333"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7414206"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Understanding of the role of focal inflammation, a treatable feature, on neuro-axonal injury, is paramount to optimize neuroprotective strategy in MS. To quantify the impact of focal inflammatory activity on the rate of neuro-axonal injury over the MS course. We quantified the annualized rates of change in peripapillary retinal nerve fiber layer, ganglion cell plus inner plexiform layer (GCIPL), whole-brain, gray matter and thalamic volumes in patients with and without focal inflammatory activity in 161 patients followed over 5 years. We used mixed models including focal inflammatory activity (the presence of at least one relapse or a new/enlarging T2-FLAIR or gadolinium- enhancing lesion), and its interaction with time adjusted by age, sex, use of disease-modifying therapies and steroids,"],"journal":["Scientific reports"],"pubmed_title":["Retinal and brain damage during multiple sclerosis course: inflammatory activity is a key factor in the first 5 years."],"pmcid":["PMC7414206"],"funding_grant_id":["PI15/0061, JR16/00006, FI16/00168"],"pubmed_authors":["Andorra M","Martinez-Lapiscina EH","Solana E","Nakamura K","Alba-Arbalat S","Camos-Carreras A","Tercero-Uribe A","Saiz A","Gomez-Andres D","Villoslada P","Blanco Y","Martinez-Heras E","Llufriu S","Pulido-Valdeolivas I","Sola-Valls N","Sepulveda M","Lampert EJ","Zubizarreta I","Sanchez-Dalmau B"],"additional_accession":[]},"is_claimable":false,"name":"Retinal and brain damage during multiple sclerosis course: inflammatory activity is a key factor in the first 5 years.","description":"Understanding of the role of focal inflammation, a treatable feature, on neuro-axonal injury, is paramount to optimize neuroprotective strategy in MS. To quantify the impact of focal inflammatory activity on the rate of neuro-axonal injury over the MS course. We quantified the annualized rates of change in peripapillary retinal nerve fiber layer, ganglion cell plus inner plexiform layer (GCIPL), whole-brain, gray matter and thalamic volumes in patients with and without focal inflammatory activity in 161 patients followed over 5 years. We used mixed models including focal inflammatory activity (the presence of at least one relapse or a new/enlarging T2-FLAIR or gadolinium- enhancing lesion), and its interaction with time adjusted by age, sex, use of disease-modifying therapies and steroids,","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2025-05-29T20:43:22.482Z","creation":"2025-05-29T20:43:22.482Z"},"accession":"S-EPMC7414206","cross_references":{"pubmed":["32770013"],"doi":["10.1038/s41598-020-70255-z"]}}