biostudies-literaturePichet Binette ANIA NIH HHSAlzheimer SocietyFoundation for the National Institutes of HealthAlzheimer&apos;s AssociationCanadian Institutes of Health Research776-785https://www.ebi.ac.uk/biostudies/studies/S-EPMC7415608biostudies-literatureUnknown89(8)<h4>Background</h4>Major prevention trials for Alzheimer's disease (AD) are now focusing on multidomain lifestyle interventions. However, the exact combination of behavioral factors related to AD pathology remains unclear. In 2 cohorts of cognitively unimpaired individuals at risk of AD, we examined which combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle (years of education or lifetime cognitive activity) related to the pathological hallmarks of AD, amyloid-β, and tau deposits.<h4>Methods</h4>A total of 115 older adults with a parental or multiple-sibling family history of sporadic AD (PREVENT-AD [PRe-symptomatic EValuation of Experimental or Novel Treatments for AD] cohort) underwent amyloid and tau positron emission tomography and answered several queBiological psychiatryAmyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease.PMC7415608R01 AG052550UF1 AG032438U19 AG032438Douglas JBreitner JCSPogossova GGervais VLafaille-Magnan MEPoirier JSpreng NFrenette JCouture DMasters CHoge RFonov VKawarabayashi TMunter LMKat JLabonte AMartins RRioux PTullo SMathieu AXu XKazazian CChhatwal JHornbeck RRaichle MSalloway SCarrier CEFeldman HTeigner EYu EJerome GCheewakriengkrai LRajah NFerdinand FAppleby MDadar MFrappier JKuder-Buletta EAisen PAnthal ESwisher LCraft SKhachaturian ZSHirohara MBerman STaddei KKarch CDebacker CGardener SDansereau CGray JHoltzman DCollins DLBedetti CVachon-Presseau EMaultaup GMontoya LSaint-Fort EFJucker MBrandt JClifford JKlunk WBBenzinger TRingman JEl-Khoury RFarlow MSigurdson WLee JHPerrin REvans ANoble JDuclair GTardif CNear JFlynn GDesautels RBrandon SDufour MNeimeyer KDaoust LAAllegri REisenberg MBuck JXiong CCuello CSparks PBarkun ATheroux LTuwaig MFranklin EFarzin SFaubert AMChrem PSuzuki KDauar-Tedeschi MMcSweeney MGant CMadjar CCourcot BMori HMorris JSavard MWolfsberger MMeyer PFGraff-Radford NMcDade ELevin JSchofield PDubuc SGoate AMaue-Dreyfus DCollins LPruessner JEdigo NSager MAToussaint JGordon RFox NShimada HGoldman JKoeppe RWan KLaske CVerfaillie SCJNorton JGiles RFontaine DFarrar AKostopoulos PGhetti BBateman RShoji MPREVENT-AD Research GroupPage VCruchaga CIturia-Medina YVenugopalan VCarmo LAyranci GMason NSPetkova MVilleneuve SNagamatsu ALeoutsakos JMBenbouhoud FMayrand GErekin-Taner NRosa-Neto PIkeuchi TKnopman DSWeiner MTam APichet Binette ABohbot VIkonomovic SBrooks WBGagne GSperling RAPishnamazi MDiBari SHOrban PTabrizi SDonahue TLee TKobe TFujii HGauthier SVogel JWChui HJack CRSalaciak AWang JMarcus DWang PCinco JWang SMiron JVallee ILepage CMaltais JRTremblay-Mercier JFagan AMathotaarachchi SMichaud DSohrabi HNewbold-Fox HShiroto TBeaudry TBellec PNilsson NPicard CDas SChakravarty MEtienne PMaillet DKasuga KNair VLeppert IAmtashar FPascoal TAD'Mello MBuckles VGurney JTariot PNDominantly Inherited Alzheimer Network (DIAN)Hassenstab JChea SDea DRoh JHBodge CMorris JCMahar LGonneaud JMontine TJGordon BThomas RGfalseAmyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease.<h4>Background</h4>Major prevention trials for Alzheimer's disease (AD) are now focusing on multidomain lifestyle interventions. However, the exact combination of behavioral factors related to AD pathology remains unclear. In 2 cohorts of cognitively unimpaired individuals at risk of AD, we examined which combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle (years of education or lifetime cognitive activity) related to the pathological hallmarks of AD, amyloid-β, and tau deposits.<h4>Methods</h4>A total of 115 older adults with a parental or multiple-sibling family history of sporadic AD (PREVENT-AD [PRe-symptomatic EValuation of Experimental or Novel Treatments for AD] cohort) underwent amyloid and tau positron emission tomography and answered several que2021-01-01T00:00:00Z2021 Apr2026-05-02T22:41:41.184Z2025-04-05T18:20:48.39ZS-EPMC74156083222887010.1016/j.biopsych.2020.01.023